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Breast density in multiethnic women presenting for screening mammography

Abstract Data on ethnic variations in breast density are limited and often not inclusive of underrepresented minorities. As breast density is associated with elevated breast cancer risk, investigating racial and ethnic difference may elucidate the observed differences in breast cancer risk among different populations. We reviewed breast density from initial screening of women from the Capital Breast Care Center and Georgetown University Hospital from 2010 to 2014. Patient demographics including race, age at screening, education, menopausal status, and body mass index were abstracted. We recorded the BI‐RADS density categories: (1) “fatty,” (2) “scattered fibroglandular densities,” (3) “heterogeneously dense,” and (4) “extremely dense.” Multivariable unconditional logistic regression was used to identify predictors of breast density. Density categorization was recorded for 2146 women over the 5‐year period, comprising Blacks (n = 940), Hispanics (n = 893), and Whites (n = 314). Analysis of subject characteristics by breast density showed that high category is observed in younger, Hispanic, nulliparous, premenopausal, and nonobese women (t‐test or chi‐square test, P‐values
Source: The Breast Journal - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Conclusions: In this cohort of women with elevated risk, high serum 25(OH)D levels and regular vitamin D supplement use were associated with lower rates of incident, postmenopausal breast cancer over 5 y of follow-up. These results may help to establish clinical benchmarks for 25(OH)D levels; in addition, they support the hypothesis that vitamin D supplementation is useful in breast cancer prevention. https://doi.org/10.1289/EHP943 About This Article Received: 09 August 2016 Revised: 23 January 2017 Accepted: 06 February 2017 Published: 06 July 2017 Address correspondence to C. R. Weinberg, 111 TW Alexander Dr., Rese...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion: In this cohort of high-risk women, high BMI was associated with lower MD that was suggestively stronger for premenopausal women. Although preliminary, these findings suggest a possible mechanism by which a lifestyle factor may influence MD, and possibly breast cancer risk, in high-risk women. Further evaluation with a larger sample size is needed to elucidate the relationships between physical activity, as well as other modifiable factors, and MD in this cohort of women. This study adds to the growing evidence supporting the inclusion of MD into breast cancer risk prediction models, in order to improve individu...
Source: Cancer Epidemiology Biomarkers and Prevention - Category: Cancer & Oncology Authors: Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Poster Presentations - Proffered Abstracts Source Type: research
Background: African American (AA) women were until recently less likely to be diagnosed with breast cancer (BC) and remain more likely to die from the disease when compared to non-Latina (nL) White (White) counterparts. High mammographic breast density (HBD) is a well-established risk factor for developing BC, but there is no consensus in the literature regarding whether HBD varies by race/ethnicity (R/E). AA women have been reported to have lower breast density compared to nL Whites, Latinas and Asians in some but not all studies. Only a handful of studies have examined factors (e.g. BMI, age, parity, hormone therapy, men...
Source: Cancer Epidemiology Biomarkers and Prevention - Category: Cancer & Oncology Authors: Tags: Health Economics, Policy, and Outcomes: Oral Presentations - Proffered Abstracts Source Type: research
Abstract Modifiable lifestyle factors may reduce the risk of developing breast cancer. Obesity is associated particularly with post-menopausal breast cancer. Diet is important, and exercise equivalent to running for up to 8 hours each week reduces the risk of breast cancer, both in its own right and through reducing obesity. Alcohol consumption may be responsible for 5.8% of breast cancers in Australia and it is recommended to reduce this to two standard drinks per day. Drinking alcohol and smoking increases the risk for breast cancer and, therefore, it is important to quit tobacco smoking. Prolonged use of combin...
Source: Med J Aust - Category: Journals (General) Authors: Tags: Med J Aust Source Type: research
Since the early 1990s the National Institute of Environmental Health Sciences and the National Cancer Institute have conducted and funded countless studies on potential environmental risk factors for breast cancer. While clear answers are still hard to come by in this highly complex field, increasingly sophisticated research questions and methods have yielded intriguing evidence.© Agence Photographique BSIP/Getty Images A suspected cluster of breast cancer cases on Long Island launched what has become a robust body of evidence on environmental risk factors for breast cancer. The hatching on this ma...
Source: EHP Research - Category: Environmental Health Authors: Tags: News Focus November 2016 Source Type: research
Abstract BACKGROUND: Morbidly obese women are at increased risk for breast cancer, and the majority of surgical weight-loss patients are older than 40 years old. OBJECTIVE: The purpose of the present study was to determine the technical and interpretive changes in mammography following bariatric surgery. SETTING: Accredited Academic Hospital. METHODS: Two breast-imaging radiologists reviewed screening mammograms performed on 10 morbidly obese women undergoing bariatric surgery both pre- and postoperatively. American College of Radiology Breast Imaging Reporting and Data System (ACR BI-RADS) density,...
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - Category: Surgery Authors: Tags: Surg Obes Relat Dis Source Type: research
CONCLUSION: The Western dietary pattern was associated with increased mammographic density among overweight-obese women. Our results might inform specific dietary recommendations for women with high mammographic density. PMID: 27500335 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Conclusions: After accounting for age, BMI, and other risk factors, black women had higher breast density than white women across all quantitative measures previously associated with breast cancer risk. These results may have implications for risk assessment and screening.
Source: JNCI - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
To further understand the factors that contribute to interindividual variation in mammographic density, we evaluated the relationship between education level and each component of the mammographic density measures. Study participants included 535 women between 40 and 65 years of age who received a mammogram for a population-based twin and family study. Mammographic density was measured from digital mammograms using a computer-assisted thresholding method. To avoid negative confounding by obesity level, we calculated BMI-adjusted mammographic measures. Thereafter, each of the mammographic density measures was t-transformed ...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Breast Cancer Source Type: research
Conclusion: Traffic-related air pollution exposure does not increase MD, indicating that if air pollution increases breast cancer risk, it is not via MD.
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Source Type: research
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