Evaluation of Prolonged Fatigue Post–West Nile Virus Infection and Association of Fatigue with Elevated Antiviral and Proinflammatory Cytokines

Viral Immunology , Vol. 0, No. 0.
Source: Viral Immunology - Category: Allergy & Immunology Tags: article Source Type: research

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eacute;ter Kertész Anett Kepner Máté Martina Tamás Süli Zsófia Lanszki Gábor Endre Tóth Anett Kuczmog Balázs Somogyi Ferenc Jakab Gábor Kemenesi The West Nile virus is endemic in multiple European countries and responsible for several epidemics throughout the European region. Its evolution into local or even widespread epidemics is driven by multiple factors from genetic diversification of the virus to environmental conditions. The year of 2018 was characterized by an extraordinary increase in human and animal cases in the Central-Eas...
Source: Viruses - Category: Virology Authors: Tags: Brief Report Source Type: research
Viruses, Vol. 12, Pages 104: An RNA Thermometer Activity of the West Nile Virus Genomic 3′-Terminal Stem-Loop Element Modulates Viral Replication Efficiency during Host Switching Viruses doi: 10.3390/v12010104 Authors: Alexandra Meyer Marie Freier Tobias Schmidt Katja Rostowski Juliane Zwoch Hauke Lilie Sven-Erik Behrens Susann Friedrich The 3′-terminal stem-loop (3′SL) of the RNA genome of the flavivirus West Nile (WNV) harbors, in its stem, one of the sequence elements that are required for genome cyclization. As cyclization is a prerequisite for the initiation of viral rep...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, the in vitro antiviral activity of sofosbuvir against West Nile virus (WNV) was determined by plaque assay (PA) and Immunodetection Assay (IA) in human cell lines and by enzymatic RdRp assay. By PA, the sofosbuvir half-maximal inhibitory concentration (IC50) was 1.2 ± 0.3 μM in Huh-7, 5.3 ± 0.9 μM in U87, 7.8 ± 2.5 μM in LN-18 and 63.4 ± 14.1 μM in A549 cells. By IA, anti-WNV activity was confirmed in both hepatic (Huh-7, 1.7 ± 0.5 μM) and neuronal (U87, 7.3 ± 2.0 μM) cell types. Sofosbuvir was confirmed to inhi...
Source: Antiviral Therapy - Category: Virology Source Type: research
Authors: Camp JV, Nowotny N Abstract Introduction: West Nile virus (WNV) is a mosquito-borne human and animal pathogen with nearly world-wide distribution. In Europe, the virus is endemic with seasonal regional outbreaks that have increased in frequency over the last 10 years. A massive outbreak occurred across southern and central Europe in 2018 with the number of confirmed human cases increasing up to 7.2-fold from the previous year, and expanding to include previously virus-free regions.Areas covered: This review focuses on potential causes that may explain the 2018 European WNV outbreak. We discuss the role gen...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
In this study, the in vitro antiviral activity of sofosbuvir against West Nile virus (WNV) was determined by plaque assay (PA) and Immunodetection Assay (IA) in human cell lines and by enzymatic RdRp assay. By PA, the sofosbuvir half-maximal inhibitory concentration (IC50) was 1.2 ± 0.3 μM in Huh-7, 5.3 ± 0.9 μM in U87, 7.8 ± 2.5 μM in LN-18 and 63.4 ± 14.1 μM in A549 cells. By IA, anti-WNV activity was confirmed in both hepatic (Huh-7, 1.7 ± 0.5 μM) and neuronal (U87, 7.3 ± 2.0 μM) cell types. Sofosbuvir was confirmed to inhi...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Publication date: Available online 7 January 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Bachir Medrouh, Ismail Lafri, Cécile Beck, Hamza Leulmi, Madjid Akkou, Lynda Abbad, Mohamed Lafri, Idir Bitam, Sylvie LecollinetAbstractWhile the epidemiology of Flaviviruses has been extensively studied in most of the Mediterranean basin, little is known about the current situation in Algeria. In order to detect the circulation of West Nile (WNV) and Usutu viruses (USUV) in Kabylia, 165 sera were collected from two wild birds species, namely the long distance migrant Turdus philomelos (son...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
ConclusionsWhile the samples analyzed in this work have strong clinical relevance, we have clearly demonstrated that sensitive malaria detection using AuNS-SERS is a practical direction for rapid in-field diagnosis of malaria infection.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
CONCLUSIONS: While the samples analyzed in this work have strong clinical relevance, we have clearly demonstrated that sensitive malaria detection using AuNS-SERS is a practical direction for rapid in-field diagnosis of malaria infection. PMID: 31923771 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - Category: Biomedical Science Authors: Tags: Adv Med Sci Source Type: research
Publication date: Available online 2 January 2020Source: Veterinary MicrobiologyAuthor(s): John Baird, Birthe Tegtmeyer, Luis Arroyo, Alexander Stang, Yannick Brüggemann, Murray Hazlett, Eike SteinmannAbstractTheiler’s disease was confirmed within a group horses located on a farm in southwestern Ontario during the summer and autumn of 2005. Five sudden deaths occurred between 3 July and 21 August, 2005, none of which were necropsied, however two of the horses showed clinical signs compatible with hepatic encephalopathy prior to death. No horse on the farm had received a biologic product of equine blood origin in...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
(Columbia University's Mailman School of Public Health) Columbia professors offer their perspective on a recent study on Pyrethroid, among the most widely used insecticides for public health control of vector-borne illnesses, including West Nile virus. While the insecticides are generally regarded as posing low health risks to humans in ordinary exposure situations, results show a 50 percent increase in total mortality and three-fold increase in heart disease deaths in persons with high urinary levels of 3-PBA. This unexpected finding merits urgent follow-up.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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