DNA Scan That Can Detect 1,800 Diseases In Newborns Raises Privacy Concerns

BOSTON (CBS) – Doctors at Brigham and Women’s Hospital are offering new parents a landmark genetic scan that screens newborns for around 1,800 conditions. But most parents are declining the controversial test. The trial allows newborns to be tested before showing symptoms of diseases, including some cancers. Robert Green, medical geneticist at Harvard and co-director of the BabySeq Project along with Alan Beggs, told CBS This Morning the scan could “absolutely” save a child’s life in the future. Robert Green, medical geneticist at Harvard and co-director of the BabySeq Project. (Image Credit: CBS This Morning) But as Green told CBS This Morning, there are also drawbacks to the program. “I would have to say I’m not 100 percent comfortable with it. What we’re really trying to do in this study is ask the question, ‘How beneficial or harmful is it to go down this road?'” Green said. Some of the potential risks include breaches of privacy and genetic discrimination. “We can’t predict what kind of discrimination is going to be occurring by the time your child grows up,” Green told CBS. “We can’t predict whether there’s some sort of privacy breaches, this information gets out and is used against your child in some sort of future scenario. And we, most importantly, we can’t predict the information’s accurate.” An innovative DNA test being performed at Brigham &Women&r...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local Brigham And Womens CBS This Morning Source Type: news

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Image courtesy of MARS Bioimaging New Zealand scientists have performed the first-ever 3-D, color X-ray on a human, using technology that could improve medical diagnostics in oncology, cardiology, neurology and orthopedics. Based on traditional black-and-white X-ray technology, the scanner incorporates the Medipix3RX detector chip, a particle-tracking technology developed for the CERN Large Hadron Collider. It was developed by the Medipix3 Collaboration, which comprises CERN in Geneva and 18 research institutions worldwide. The scanner records the energy of each photon as it collides with pixels while the shutter...
Source: Mass Device - Category: Medical Devices Authors: Tags: Blog Cardiovascular Diagnostics Imaging Neurological Orthopedics Research & Development CERN MARS Bioimaging Source Type: news
DISCUSSION: Although BCC is the most common skin cancer, it is usually a local disease and treated with local measures. Metastatic BCC is extremely rare, and in cases when surgical resection or local radiation are not viable options, chemotherapeutic agents typically offer very limited improvement. Vismodegib is an oral selective sonic hedgehog pathway inhibitor that shows benefit in patients with locally advanced or metastatic disease. PMID: 30005721 [PubMed - in process]
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
This study was not designed to explain whether supplementing with vitamin D will protect against asbestosis. This new research also does not examine if taking vitamin D will slow down the progression of existing ILD. Still, there are a lot of good reasons to pay attention to the sunshine vitamin. Regardless of whether a person has been exposed to asbestos, no one should ignore very low vitamin D levels. People already diagnosed with an asbestos-related cancer, may benefit from a quick check of vitamin D levels. According to the medical literature, up to 80 percent of people with cancer may be vitamin D deficient. People ca...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.8b00392
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
(Wiley) Androgen deprivation therapy for the treatment of prostate cancer can lead to loss of muscle and bone mass. In a recent Scandinavian Journal of Medicine&Science in Sport study of elderly patients undergoing the treatment, playing football -- or what's known as soccer in the United States -- over a 5-year period was linked with preserved bone mineral density (BMD) in the neck of the leg's femur.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Cancers, Vol. 10, Pages 234: Morphomechanical Alterations Induced by Transforming Growth Factor-β1 in Epithelial Breast Cancer Cells Cancers doi: 10.3390/cancers10070234 Authors: Mariafrancesca Cascione Valeria De Matteis Chiara C. Toma Stefano Leporatti The Epithelial to mesenchymal transition (EMT) is the process that drives epithelial tumor cells to acquire an invasive phenotype. The role of transforming growth factor-β1 (TGF-β1) in EMT is still debated. We used confocal laser scanning microscopy and scanning force spectroscopy to perform a morphomechanical analysis on epithelial bre...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionBased on currently available evidence, there is insufficient evidence to support the prognostic value of texture analysis in18F-FDG PET in lung cancer. Further studies implementing well-established methodologies and statistical evidence are warranted for proper validation of these promising imaging biomarkers.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
AbstractObjective2-Fluorine-18-fluoro-2-deoxy-d-glucose positron emission tomography (18F-FDG PET) imaging is not considered useful for assessing bladder cancer due to the physiological uptake of18F-FDG in the bladder. Despite reports of the detection of bladder cancer by washing out18F-FDG from the bladder, such methods are invasive and impractical in the routine practice. The purpose of this study was to evaluate prospectively the utility of oral hydration with 500  mL of water and voiding-refilling, a minimally invasive method that we introduced to enable detection of residual invasive bladder cancer on delayed18F-...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
CONCLUSION: This is the first case to our knowledge describing both such lesions in one patient and the first case describing the use of 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL)-PSMA PET/CT to detect IPAS. Furthermore we highlight the value of nuclear medicine diagnostic work up in complex cases. PMID: 30006647 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
CONCLUSION: A method of tumor size determination, using PHL on 18F-FDG PET/CT, showed more linear relationship and smaller size differences with pathology than MRI (average 0.6 vs. 1.9cm). It provides sufficient reliability and reproducibility for measuring tumor size in breast cancer. PMID: 30006644 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
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