N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays
AbstractSTUDY QUESTIONIs there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity usingin vitro assays?SUMMARY ANSWERN-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structuresin vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium.WHAT IS KNOWN ALREADYHuman endometrium contains a small population of clonogenic, self-renewing epithelial cells with high proliferative potential that differentiate into large gland-like structures, but their identity and location is unknown. Stage-specific embryonic antigen-1 (SSEA-1) distinguishes the epithelium of basalis from functionalis and is a marker of human post-menopausal (Post-M) endometrial epithelium.STUDY DESIGN, SIZE, DURATIONProspective observational study of endometrial epithelial cells obtained from hysterectomy samples taken from 50 pre-menopausal (Pre-M) and 24 Post-M women, of which 4 were from women who had taken daily estradiol valerate 2 mg/day for 8 weeks prior.PARTICIPANTS/MATERIALS, SETTING, METHODSGene profiling was used to identify differentially expressed surface markers between fresh EpCAM (Epithelial Cell Adhesion Molecule)-magnetic bead-selected basalis-like epithelial cells from Post-M endometrium compared with predominantly functionalis epithelia...
I have had insomnia for years, which I put down to the menopause. Now I ’ve come across research that suggests interrupted sleep in middle-age increases the risk of Alzheimer’s. What should I do? I am 62.
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02529G, CommunicationKun Fang, Shanchao Wu, Guoqiang Dong, Ying Wu, Shuqiang Chen, Jianhe Liu, Wei Wang, Chunquan Sheng The development of small molecules for cancer immunotherapy is highly challenging and indoleamine 2,3-dioxygenase 1 (IDO1) represents a promising target. Inspired by the synergistic effects between IDO1 inhibitors and traditional... The content of this RSS Feed (c) The Royal Society of Chemistry
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Jacob Thompson, the boy who got thousands of Christmas cards from charmed fans this fall, has died after a long battle with cancer.
Dalton Trans., 2017, Accepted Manuscript DOI: 10.1039/C7DT02616A, PaperWeijia Niu, I-Ting Teng, Xigao Chen, Weihong Tan, Adam Steven Veige A novel cationic NHC-Au(I) complex was synthesized and studied for its antitumor activity. For all the cell lines tested, cationic NHC-Au(I) complex 2 shows much higher cytotoxicity than its neutral... The content of this RSS Feed (c) The Royal Society of Chemistry
Dalton Trans., 2017, Accepted Manuscript DOI: 10.1039/C7DT03229C, PaperKarolina Kowalczyk, Andrzej Blauz, Wojciech M. Ciszewski, Anna Wieczorek, Blazej Rychlik, Damian Plazuk A series of ferrocenyl and ruthenocenyl conjugates with colchicine bearing 1,2,3-triazole moiety were synthesized and their anticancer properties were evaluated. We found that the most potent metallocenyl derivativesRc4 and... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Soc. Rev., 2018, Advance Article DOI: 10.1039/C7CS00550D, Review ArticleSerge Mignani, Joao Rodrigues, Helena Tomas, Maria Zablocka, Xiangyang Shi, Anne-Marie Caminade, Jean-Pierre Majoral Overview of the use of dendrimers in combination with encapsulated and conjugated natural products and analogues as anti-cancer agents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7CC08526E, CommunicationRavikumar Govindan, Meisam Bagheri, Deepak Kumar Saini, Harinath Chakrapani Thera/NO, a small molecule that is activated by hydrogen peroxide to generate nitric oxide (NO) as well as a fluorescence signal is reported. Using cancer and primary cells, we show... The content of this RSS Feed (c) The Royal Society of Chemistry
Jacob Thompson battled neuroblastoma for four years, and people around the world pitched in to bring him joy in his final days
Jacob Thompson spent nearly half of his short life battling cancer. The 9-year-old boy, who loved penguins, died Sunday, four years after he was diagnosed with Stage 4 neuroblastoma, a rare cancer that affects mostly young children. As his family had expected, Thompson didn’t live long enough for Christmas, a holiday he loves. But shortly before his death, […]Related:Risk of stillbirth is double in pregnant women who sleep on their backs, study findsA dying vet needed CPR. Hidden video shows his nurse laughing instead.The truth behind the ‘first marijuana overdose death’ headlines
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