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N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays

AbstractSTUDY QUESTIONIs there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity usingin vitro assays?SUMMARY ANSWERN-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structuresin vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium.WHAT IS KNOWN ALREADYHuman endometrium contains a small population of clonogenic, self-renewing epithelial cells with high proliferative potential that differentiate into large gland-like structures, but their identity and location is unknown. Stage-specific embryonic antigen-1 (SSEA-1) distinguishes the epithelium of basalis from functionalis and is a marker of human post-menopausal (Post-M) endometrial epithelium.STUDY DESIGN, SIZE, DURATIONProspective observational study of endometrial epithelial cells obtained from hysterectomy samples taken from 50 pre-menopausal (Pre-M) and 24 Post-M women, of which 4 were from women who had taken daily estradiol valerate 2 mg/day for 8 weeks prior.PARTICIPANTS/MATERIALS, SETTING, METHODSGene profiling was used to identify differentially expressed surface markers between fresh EpCAM (Epithelial Cell Adhesion Molecule)-magnetic bead-selected basalis-like epithelial cells from Post-M endometrium compared with predominantly functionalis epithelia...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research

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This debate pack outlines progress so far in implementing the cancer strategy and provides statistics on survival rates and the NHS cancer workforce. It also collates commentary and analysis from official, parliamentary and third sector organisations.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
ABSTRACT Deciphering the complex milieu that makes up the tumor microenvironment (TME) and the signaling engaged by TME cytokines continues to provide novel targets for therapeutic intervention. The IL‐6 family member Oncostatin M (OSM) has recently emerged as a potent driver of tumorigenesis, metastasis and therapy failure, molecular programs most frequently attributed to IL‐6 itself. In a recent issue of The Journal of Pathology, Kucia‐Tran et al. describe how elevated Oncostatin M receptor (OSMR) expression results in a feed‐forward loop involving the de novo production of both OSM and OSMR to facilitate aggress...
Source: The Journal of Pathology - Category: Pathology Authors: Tags: Invited Commentary Source Type: research
This NIHR Signal finds that for western high-income countries such as the UK, an estimated 15% to 16% of cancers could be avoided by preventing diabetes, obesity or excess weight. Although the links between high BMI, diabetes and cancer have been known for some time, this study presents the first calculations of attributable risk for 175 countries. This represents the proportion of cancers that could be prevented if the risk factors were eliminated.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
According to this study: Current or recent users of hormonal contraceptives are at higher risk for breast cancer than women who have never used hormonal contraceptives.The risk increases with the duration of use.
Source: AJN - Category: Nursing Tags: Journal Watch Source Type: research
Oncology Nurses' Knowledge, Confidence, and Practice in Addressing Caregiver Strain and Burden
. Oncol Nurs Forum. 2018 Mar 01;45(2):187-196 Authors: Irwin MM, Dudley W, Northouse L, Berry DL, Mallory GA Abstract OBJECTIVES: To describe nurses' practices, confidence, and knowledge of evidence-based interventions for cancer caregiver strain and burden and to identify factors that contribute to these aspects. 
. SAMPLE & SETTING: 2,055 Oncology Nursing Society members completed an emailed survey.
. METHODS & VARIABLES: Pooled analysis of survey results. Variables included the bas...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: Oncol Nurs Forum Source Type: research
ConclusionIt is feasible and safe to use this novel, flexible, single‐arm robot in performing a transoral robotic radical tonsillectomy and retropharyngeal lymph node dissection.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: OPERATIVE TECHNIQUES Source Type: research
CONCLUSIONS: The combination of TBx and SBx achieved the best results for the detection and prognosis of PCa-s. The use of SBx alone would have missed the detection of PCa-s in 12% of patients. PMID: 29463177 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
CONCLUSIONS: Low-dose brachytherapy offers good short- to intermediate-term cancer control in selected men with localized PCa. Further studies are needed for safety analyses and for comparison with other treatment modalities. PMID: 29463165 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
A Queensland mother-of-two went through menopause at just 32 after she had both of her ovaries removed due to a high-risk of cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodr íguez, Yvette van Kooyk, Sandra J. van Vliet
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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