High gonadotropin dosage does not affect euploidy and pregnancy rates in IVF PGS cycles with single embryo transfer

AbstractSTUDY QUESTIONDoes high gonadotropin dosage affect euploidy and pregnancy rates in PGS cycles with single embryo transfer?SUMMARY ANSWERHigh gonadotropin dosage does NOT affect euploidy and pregnancy rates in PGS cycles with single embryo transfer.WHAT IS KNOWN ALREADYPGS has been proven to be the most effective and reliable method for embryo selection in IVF cycles. Euploidy and blastulation rates decrease significantly with advancing maternal age. In order to recruit an adequate number of follicles, the average dosage of gonadotropins administered during controlled ovarian stimulation in IVF cycles often increases significantly with advancing maternal age.STUDY DESIGN, SIZE, AND DURATIONA retrospective study of SNP (Single Nucleotide Polymorphism) PGS outcome data from blastocysts biopsied on day 5 or day 6 was conducted to identify differences in euploidy and clinical pregnancy rates. Seven hundred and ninety four cycles of IVF treatment with PGS between January 2013 and January 2017 followed by 651 frozen embryo transfers were included in the study (506 patients, maternal age (y.o.) – 37.2 ± 4.31).PARTICIPANTS/MATERIALS, SETTING, METHODSA total of 4034 embryos were analyzed (5.1 ± 3.76 per case) for euploidy status. All embryos were vitrified after biopsy, and selected embryos were subsequently thawed for a hormone replacement frozen embryo transfer cycle. All cycles were analyzed by total gonadotropin dosage (<3000 IU, 3000 –5000 IU and>5000 IU), by n...

Source: Human Reproduction - October 12, 2017 Category: Reproduction Medicine Source Type: research