Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence

ConclusionsTheADH1B Arg/Arg genotype and theALDH2 Glu/Lys genotype were positive determinants of fatty liver in the subjects. These results suggest that slow ethanol and acetaldehyde metabolism accelerates the development of alcoholic fatty liver in heavy drinkers.

Source: Journal of Gastroenterology - October 23, 2017 Category: Gastroenterology Source Type: research