Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice

We investigated the effects of nickel oxide nanoparticles (NiONPs) on the pulmonary inflammopathology. NiONPs were intratracheally installed into mice, and lung injury and inflammation were evaluated between 1 and 28 d. NiONPs caused significant increases in LDH, total protein, and IL-6 and a decrease in IL-10 in the BALF and increases in 8-OHdG and caspase-3 in lung tissues at 24h. Airway inflammation was present in a dose-dependent manner from the upper to lower airways at 24h of exposure as analyzed by SPECT.

Source: Nanomedicine : Nanotechnology, Biology, and Medicine - October 23, 2017 Category: Nanotechnology Authors: Kuan-Jen Bai, Kai-Jen Chuang, Jen-Kun Chen, His-En Hua, Yen-Ling Shen, Wei-Neng Liao, Chii-Hong Lee, Kuan-Yuan Chen, Kang-Yun Lee, Ta-Chih Hsiao, Chih-Hong Pan, Kin-Fai Ho, Hsiao-Chi Chuang Source Type: research