Total darkness at night key to success of breast cancer therapy, study shows

Exposure to light at night, which shuts off nighttime production of the hormone melatonin, renders breast cancer completely resistant to tamoxifen, a widely used breast cancer drug, says a new study. Melatonin by itself delayed the formation of tumors and significantly slowed their growth, researchers report, but tamoxifen caused a dramatic regression of tumors in animals with either high nighttime levels of melatonin during complete darkness or those receiving melatonin supplementation during dim light at night exposure.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Erik W. J. Mollen, Jonathan Ient, Vivianne C. G. Tjan-Heijnen, Liesbeth J. Boersma, Lucio Miele, Marjolein L. Smidt, Marc A. G. G. Vooijs
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Aryl hydrocarbon receptor ligand 5F 203 induces the expression of putative tumor suppressor cytoglobin (CYGB) and promotes anticancer activity and apoptosis in vivo and in vitro. CYGB promotes 5F 203 –mediated cell death, caspase‐3/‐7 activation, proapoptotic gene expression, lysosomal membrane permeabilization (LMP), and cathepsin B release in triple negative breast cancer (TNBC) cells. These findings suggest that AhR ligands such as 5F 203 upregulate CYGB to confer TNBC cell death. AbstractNearly 40 000 women die annually from breast cancer in the United States. Clinically available targeted breast cancer thera...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
Abstract Manipulating the assembly of gold nanoparticles (AuNPs) for maximizing the photothermal effect is a promising strategy for cancer therapy. Herein, taking advantage of the well-known tetrazole/alkene photo-click chemistry, we for the first time demonstrated that small AuNPs (23 nm) decorated with both 2, 5-diphenyltetrazole and methacrylic acid on the surface could form covalently cross-linked aggregates upon laser irradiation (λ = 405 nm). The in vitro studies indicated that the light-triggered assembling remarkably shifted the surface plasmon resonance of AuNPs to near-infrared (NIR) regions, whic...
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research
This study evaluates a correlation between family history, micronutrients intake, and alternative therapies with genetic instability, before and during breast cancer treatment. For this study, a total of 150 women were selected. Among those, 50 women were breast cancer patients on chemotherapy, while 50 breast cancer patients were on radiotherapy, and 50 were healthy females. All the participants signed the informed consent form and answered the public health questionnaire. Samples of buccal epithelial and peripheral blood cells were collected and analyzed through micronucleus and comet assays. The cells were evaluated for...
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Tags: Appl Biochem Biotechnol Source Type: research
Conclusion: Propolis extracts may be important economically, allowing a relatively inexpensive cancer treatment associated to lower concentrations of drugs. In this review, the activity and mechanisms of action of propolis and CAPE on breast cancer cells are discussed.
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research
Abstract Reducing the adverse effects of chemotherapy on normal cells such as endothelial cells is a determinant factor of treatment success especially in pregnant women. In this regard, modulatory effect of L-arginine on various cancers is still a controversial topic in cancer therapy. So, this study aimed to compare the effect of L-arginine treatment alone and in combination with 5-fluorouracil (5-FU) on the survival and angiogenesis of primary human umbilical vein endothelial cells (HUVECs) and the breast cancer cell line of MDA-MB-468. Combinations of L-arginine and 5-FU increased cell survival in HUVECs but i...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research
ConclusionApplication of cytostatic drugs in combination with adaptogenic plant extracts induced significant changes in transcriptome-wide microarray profiles of neuroglial cells. These changes indicate on potential beneficial effects of adaptogens on FEC induced adverse events in cancer chemotherapy.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
In this study we further explore the inhibitory effects of this molecule in cancer cells. We found that Pimozide inhibited cell proliferation in a dose- and time-dependent manner in MDA-MB-231 breast cancer cells and A549 lung cancer cells. Furthermore, we found that Pimozide also promoted apoptosis as demonstrated by cell cycle arrest and induction of double-strand DNA breaks but did not result in any effect in the non-transformed MCF10A breast cell line. In order to shed new lights into the molecular pathways affected by Pimozide, we show that Pimozide downregulated RAN GTPase and AKT at both protein and mRNA levels and ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
International Journal of Dermatology, Volume 57, Issue 12, Page e165-e167, December 2018.
Source: International Journal of Dermatology - Category: Dermatology Authors: Tags: Correspondence Source Type: research
New J. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8NJ03350A, PaperDipranjan Laha, Kunal Pal, Angshuman Ray Chowdhuri, Pravat Kumar Parida, Sumanta Kumar Sahu, Kuladip Jana, Parimal Karmakar Curcumin has shown therapeutic activity against triple negative breast cancer cell (TNBC), but it shows low efficacy and low bioavailability when administered as a free drug. We have developed a... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
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