Single ‐Dose Bone Pharmacokinetics of Vancomycin in a Porcine Implant‐Associated Osteomyelitis Model

In conclusion, Staphylococcus aureus implant‐associated osteomyelitis was found to reduce vancomycin bone penetration, especially in the implant cavity. These findings suggest that it may be unsafe to rely solely on vancomycin therapy when treating acute osteomyelitis. Particularly when metaphyseal cavities are present, surgical debridement seems necessary. This article is protected by copyright. All rights reserved

Source: Journal of Orthopaedic Research - October 23, 2017 Category: Orthopaedics Authors: Mats Bue, Pelle Hanberg, Janne Koch, Louise Kruse Jensen, Martin Lundorff, Bent Aalb æk, Henrik Elvang Jensen, Kjeld Søballe, Mikkel Tøttrup Tags: Research Article Source Type: research