Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers

Conclusions:
Synaptic dysfunction (assessed via neurogranin) may be an early pathologic process in age-related neurodegeneration, and a sensitive marker of age-related cognitive abilities, potentially preceding or even acting independently from AD pathogenesis. Synaptic functioning may be a useful early marker of cognitive aging and possibly a target for future brain aging interventions.

Source: Neurology - October 23, 2017 Category: Neurology Authors: Casaletto, K. B., Elahi, F. M., Bettcher, B. M., Neuhaus, J., Bendlin, B. B., Asthana, S., Johnson, S. C., Yaffe, K., Carlsson, C., Blennow, K., Zetterberg, H., Kramer, J. H. Tags: Alzheimer's disease, Cognitive aging ARTICLE Source Type: research