Mixed neuropathologies and associations with domain-specific cognitive decline

Conclusions:
ADNC + LBD (but not ADNC + VBI) was associated with poorer executive function and attention compared to other pathology groupings. However, the effect of co-occurring pathologies on cognitive trajectories may depend on the severity of ADNC. Future studies using antemortem biomarkers should seek to replicate these neuropathologic observations.

Source: Neurology - October 23, 2017 Category: Neurology Authors: Brenowitz, W. D., Hubbard, R. A., Keene, C. D., Hawes, S. E., Longstreth, W. T., Woltjer, R. L., Kukull, W. A. Tags: Prognosis, Alzheimer's disease, Dementia with Lewy bodies, Vascular dementia, Cognitive neuropsychology in dementia ARTICLE Source Type: research