Extending indication of cyclin-dependent kinase 4/6 inhibitors in the adjuvant and neoadjuvant setting
Purpose of review: A burst of recent activity has surrounded the study of cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors for the treatment of metastatic breast cancer. The success of these drugs in the metastatic setting has pushed the evaluation of these agents in early-stage disease. The use of CDK 4/6 inhibitors as neoadjuvant and adjuvant therapy is a hot topic and several studies are underway.
Recent findings: Ongoing studies are exploring the addition of CDK 4/6 inhibitors to endocrine therapy in early breast cancer.
Summary: Identification of the optimal treatment combinations is the goal of current research. Finding biomarkers for patients’ selection will be the goal of future research.
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: BREAST CANCER: Edited by Giuseppe Curigliano Source Type: research
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