B3 vitamin component fights carcinogen action in human cells, says research

(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Brazilian scientists investigate tumoral development caused by benzo[a]pyrene, a hydrocarbon present in cigarette smoke, automotive exhaust, burnt wood fumes and barbecued meat. Culture of human lung cells was exposed to the agent for a week; the preventive role of nicotinamide riboside halted the damaging effects derived from alterations in genetic expression and cell metabolism.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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As backyard cookout season kicks into high gear, many people may be eyeing their sizzling burgers and dogs with suspicion. And for good reason: a number of studies published in the past two decades have turned up evidence that eating charred, smoked, and well-done meat could raise cancer risk—pancreatic, colorectal, and prostate cancers, in particular. A 2010 review of the evidence on cancer and “well-done” meat, conducted by researchers at Vanderbilt University, concluded that “the majority of these studies have shown that high intake of well-done meat and high exposure to meat carcinogens, particu...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer Diet & Fitness Nutrition Source Type: news
As a high school junior, I was shown the guts of an implantable defibrillator. That day, I quit my pursuit of a career in medicine to pursue one in medical device design. OK, so my life didn’t go quite that linearly, but many years later I continue to work on life-improving technologies from the consulting side of medical device design. This pursuit continues to be a great passion. The medical device market is in the popular press spotlight these days. Actually, it’s more of a target. Netflix’s documentary The Bleeding Edge explored whether the 510(k) FDA clearance proc...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
ConclusionHealth professionals must consider this pathology when evaluating a burn scar or a chronic wound, performing a biopsy when suspicion is high. An early diagnosis, a prompt surgical intervention and a greater vigilance are the keys to success and survival.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Abstract Cyclophosphamide is an alkylating agent used in the treatment of solid and haematological malignancies and as an immunosuppressive agent. As a prodrug it is dependent on bioactivation to the active phosphoramide mustard metabolite to elicit its therapeutic effect. This focused review will highlight the evidence for the role of germline pharmacogenetic variation in both plasma pharmacokinetics and clinical outcomes. There is a substantial signal from 13 pharmacokinetic and 17 therapeutic outcome studies, in contexts as diverse as haematological malignancy, breast cancer, systemic lupus erythematosus and my...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Br J Clin Pharmacol Source Type: research
BOSTON (CBS) — Researchers in Finland have developed a so-called “artificial nose” that they believe can help sniff out brain cancer during surgery. Surgeons often use an electric knife, particularly when operating on the brain. As the knife cuts, it burns through tissue, releases molecules into the air in the form of surgical smoke. Researchers developed a way to feed this smoke into a measuring system that has been taught to recognize smoke molecules from malignant tissue versus that from healthy tissue. In a study of almost 700 tissue samples, the device was at least 83 percent accurate at finding the ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local brain tumors Dr. Mallika Marshall Source Type: news
By Wendell BalderasBANGKOK, Thailand, Jun 14 2019 (IPS) The U.S. Food and Drug Administration’s (FDA) decision authorizing the sale of Philip Morris International (PMI)’s heated tobacco system, IQOS, in the United States inadvertently puts a foot in the door to increase sales of new tobacco products in the developing world. In April this year, the FDA authorized the sale of IQOS heated tobacco products in the US. However, it clarified that it has not approved IQOS as a ‘modified risk tobacco product’ (MRTP). But PMI is riding on this ‘US-FDA approved for sale’ of its IQOS as also safer ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Development & Aid Environment Featured Global Headlines Health TerraViva United Nations Women's Health Source Type: news
Cutaneous malignant melanoma (CM) is the leading cause of skin cancer –related mortality and accounts for approximately 1,250 deaths in Canada each year. It is also one of few cancers continuing to display rates of increasing incidence throughout the world. The past decade has brought significant growth in our understanding of the pathogenesis and clinical managemen t of CM. This evidence-based review synthesizes that knowledge, beginning with a review of the epidemiology and etiology of the disease followed by a broad review of the roles of diagnostic imaging in its management.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Tags: Continuing Medical Education Source Type: research
Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2019 Jun 04;170(11):770-778 Authors: Burns RB, Olumi AF, Owens DK, Smetana GW Abstract Prostate cancer is the third most common cancer type in the United States overall, accounting for 9.5% of new cancer cases and 5% of cancer deaths. The goal of prostate-specific antigen (PSA)-based screening is to identify early-stage disease that can be treated successfully. The U.S. Preventive Services Task Force (USPSTF) reviewed evidence on the benefits and harms of PSA-based screening and treatment of screen-detected prostate cancer. It found...
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
It’s a Wednesday evening in Brooklyn, NY, and bars are dead. Tea-candle-dotted tables sit empty, waiting for a happy hour rush that isn’t. But tucked away on a side street, hours before its midnight closing time, a bar called Getaway hums with activity. Metal straws clink against ice and cocktail shakers rattle as patrons belly up to the marble bar. A woman fresh out of work reads and nurses a drink at a corner table. An early-thirties couple chats over a pre-dinner beverage, holding hands in the flattering dim lighting. This is New York City’s first permanent booze-free bar, and no one is drinking alcoho...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized public health Source Type: news
Discussion: Sunscreen use among Native Americans (36.4%) appears to be greater than other skin of color users, but less than that of non-Hispanic Whites (40.4%). We postulate that this may be due to the respondents living in states with high UV burden, or an intrinsically greater propensity to burn. Native American populations tend to lack skin cancer screenings by dermatologists and understanding of skin cancer etiology. Efforts are needed to encourage education and dermatologic services to Native American reservations. J Drugs Dermatol. 2019;18(5):420-423. PMID: 31141849 [PubMed - in process]
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
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