Inhibition of smooth muscle force generation by focal adhesion kinase (FAK) inhibitors in the hyperplastic human prostate.

In conclusion, α1-adrenergic smooth muscle contraction or its regulation involves FAK in the human prostate. Consequently, FAK may be involved in pathophysiology of LUTS, and in current or future LUTS therapies.
PMID: 25056351 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - July 23, 2014 Category: Urology & Nephrology Authors: Kunit T, Gratzke C, Schreiber A, Strittmatter F, Waidelich R, Rutz B, Loidl W, Andersson KE, Stief CG, Hennenberg M Tags: Am J Physiol Renal Physiol Source Type: research