Sensorimotor gating deficits in “two-hit” models of schizophrenia risk factors

Genetic and environmental models of neuropsychiatric disease have grown exponentially over the last 20years. One measure that is often used to evaluate the translational relevance of these models to human neuropsychiatric disease is prepulse inhibition of startle (PPI), an operational measure of sensorimotor gating. Deficient PPI characterizes several neuropsychiatric disorders but has been most extensively studied in schizophrenia. It has become a useful tool in translational neuropharmacological and molecular genetics studies because it can be measured across species using almost the same experimental parameters.

Source: Schizophrenia Research - October 22, 2017 Category: Psychiatry Authors: Asma Khan, Susan B. Powell Source Type: research