HDL functionality in type 1 diabetes

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by absence of insulin secretion due to destruction of the pancreatic beta-cells. Patients with T1D exhibit an increased risk for cardiovascular disease (CVD) compared with non-diabetic subjects. It has been established that low concentration of high ‐density lipoprotein cholesterol (HDL-C), an independent risk marker of CVD, coincides with a reduced protective capacity against oxidative stress. However, conflicting results have been reported on the prevalence of low HDL-C levels in T1D.

Source: Atherosclerosis - October 21, 2017 Category: Cardiology Authors: Shiva Ganjali, Geesje M. Dallinga-Thie, Luis E. Simental-Mend ía, Maciej Banach, Matteo Pirro, Amirhossein Sahebkar Tags: Review article Source Type: research