Expression of aromatase in the rostral ventromedial medulla and its role in the regulation of visceral pain.

CONCLUSIONS: Our observations confirmed the expression of aromatase in the RVM, a pivotal brain region in descending modulation of pain and opioid analgesia. The results support the hypothesis that locally produced estrogens in the RVM may be involved in the maintenance of chronic visceral hyperalgesia and the downstream signaling may involve phosphorylation of MOR. PMID: 29047208 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29047208?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - October 18, 2017 Category: Neuroscience Authors: Gao P, Ding XW, Dong L, Luo P, Zhang GH, Rong WF Tags: CNS Neurosci Ther Source Type: research