Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.

Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus. J Inorg Biochem. 2017 Oct 12;178:54-62 Authors: Sun X, Li J, Zhao H, Wang Y, Liu J, Shao Y, Xue Y, Xing M Abstract Arsenic or copper is one of the most highly toxic pollution that can cause dysfunction to brains, however, the exact mechanism remains unclear. The aim of the study is to investigate the mechanisms of arsenic or/and copper-induced oxidative stress, inflammation and autophagy in chicken brains and elucidate the interactions between arsenic and copper. A total of 72 1-day-old Hy-line chickens were divided into four groups (18 chickens per group) treated with 30mg/kg arsenic trioxide (As2O3) or/and 300mg/kg copper sulfate (CuSO4) for 12weeks. Histological signs of inflammation were found in the cerebrum, cerebellum and brainstem exposure to arsenic or/and copper. The malondialdehyde (MDA) content were up-regulation, whereas oxidative damage parameters total antioxidant capacity (T-AOC), glutathione (GSH), the inhibition ability of hydroxyl radical (OH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were significantly decreased (P
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research

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