A Simulation Study of Propofol Effect-Site Concentration for Appropriate Sedation in Pediatric Patients Undergoing Brain MRI: Pharmacodynamic Analysis.

CONCLUSION: The required propofol Ce₅₀ for applying monitors during the preparation phase before the start of MRI was higher than the propofol Ce₅₀ required during the scanning phase. During low-intensity stimulation phases, such as scanning, propofol bolus dose should be strictly titrated not to exceed the propofol Ce that can lead to oxygen desaturation because of the relatively low propofol Ce (Ce₉₅, 1.43 μg/mL) required for sedation in most patients. PMID: 29047247 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29047247?dopt=Abstract

Source: Yonsei Medical Journal - October 21, 2017 Category: Universities & Medical Training Authors: Na SH, Song Y, Kim SY, Byon HJ, Jung HH, Han DW Tags: Yonsei Med J Source Type: research