Pharmacodynamic Monitoring Predicts Outcomes of CCR5 Blockade as GVHD Prophylaxis

• A pharmacodynamic assay that quantifies chemokine receptor blockade is described.• Chemokine receptor blockade insufficiency was predictive of worse clinical outcomes.• Baseline recipient T-cell CCR5 expression levels were also predictive of clinical outcomes.

Source: Biology of Blood and Marrow Transplantation - October 20, 2017 Category: Hematology Authors: Austin P. Huffman, Lee P. Richman, Lisa Crisalli, Alex Ganetsky, David L. Porter, Robert H. Vonderheide, Ran Reshef Source Type: research