Whole body physiologically based modelling of beta ‐blockers in the rat: Events in tissues and plasma following an intravenous bolus dose

Conclusions and ImplicationsPBPK modelling is a very powerful tool to aid drug discovery and development of therapeutic agents in animals and humans. However, careful consideration of the assumptions made during the modelling exercise is essential.

Source: British Journal of Pharmacology - October 20, 2017 Category: Drugs & Pharmacology Authors: S Y A Cheung, T Rodgers, L Aarons, I Gueorguieva, G L Dickinson, S Murby, C Brown, B Collins, M Rowland Tags: RESEARCH PAPER Source Type: research