Assessment of risk of bias in quasi-randomized controlled trials and randomized controlled trials reported in the Korean Journal of Anesthesiology between 2010 and 2016.

Assessment of risk of bias in quasi-randomized controlled trials and randomized controlled trials reported in the Korean Journal of Anesthesiology between 2010 and 2016. Korean J Anesthesiol. 2017 Oct;70(5):511-519 Authors: Kim JH, Kim TK, In J, Lee DK, Lee S, Kang H Abstract Bias affects the true intervention effect in randomized controlled trials (RCTs), making the results unreliable. We evaluated the risk of bias (ROB) of quasi-RCTs or RCTs reported in the Korean Journal of Anesthesiology (KJA) between 2010 and 2016. Six kinds of bias (selection, performance, detection, attrition, reporting, and other biases) were evaluated by determining low, unclear, or high ROB for eight domains (random sequence generation, allocation concealment, blinding of participants, blinding of personnel, blinding of outcome assessment, incomplete outcome data, selective reporting, and other bias) according to publication year. We identified 296 quasi-RCTs or RCTs. Random sequence generation was performed better than allocation concealment (51.7% vs. 20.9% for the proportion of low ROB, P < 0.001 and P = 0.943 for trend, respectively). Blinding of outcome assessment was superior to blinding of participants and personnel (42.9% vs. 15.5% and 23.0% for the proportion of low ROB, P = 0.026 vs. P = 0.003 and 0.896 for trend, respectively). Handling of incomplete outcome data was performed best with the highest proportion of low ROB (84.8%). Selective repo...
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research