Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis.

CONCLUSION: Our results showed that when we control for the influence of the ancestral haplotype 8.1, no polymorphism was demonstrated to be associated with EOMG development within the MHC region suggesting that the HLA-B*08:01 allele is the unique genetic factor within the HLA region responsible for EOMG development in patients who carry the ancestral haplotype 8.1. Our study also identified two novel polymorphisms as risk factors for MG HLA-B*08:01 positive patients which regulate the expression of the OVCH1 and CNYP2 genes.
PMID: 29037440 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - October 13, 2017 Category: Allergy & Immunology Authors: Varade J, Wang N, Lim CK, Zhang T, Zhang Y, Liu X, Piehl F, Matell R, Cao H, Xu X, Hammarström L Tags: J Autoimmun Source Type: research