Trends In Opioid Prescribing In Primary Care Patients With Knee Osteoarthritis: A Population Based Observational Study

Opioid prescribing has markedly increased in UK and worldwide, predominantly for chronic non-cancer pain (CNCP). CNCP includes conditions such as fibromyalgia, low back pain and osteoarthritis (OA). Evidence suggests that widespread use of opioids in CNCP is associated with risks of diversion and abuse, overdose and death. However, opioid prescribing data in specific medical conditions are limited and no study has examined the trends of prescribing in patients with OA in UK. OA affects around 7 million people in the UK with knee joint being most commonly affected.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research

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Publication date: September 2018Source: Molecular Genetics and Metabolism Reports, Volume 16Author(s): Maria Bleier, Nataliya Yuskiv, Tina Priest, Marioara Angela Moisa Popurs, Sylvia Stockler-Ipsiroglu, BC Children's Hospital, The University of British ColumbiaAbstractMorquio B disease (MBD) or Mucopolysaccharidosis type IV B (MPS IV B) is caused by particular GLB1 mutations specifically affecting the affinity of beta-galactosidase to keratan sulphate, resulting in dysostosis multiplex resembling Morquio A (MPS IV A) disease (GALNS deficiency). Additional neuronopathic features of GM1 II/III (juvenile/adult) gangliosidosi...
Source: Molecular Genetics and Metabolism Reports - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Felix Preisser, Elio Mazzone, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Michele Marchioni, Thomas Steuber, Fred Saad, Francesco Montorsi, Shahrokh F. Shariat, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I. KarakiewiczAbstractCytoreductive radical prostatectomy (CRP) may offer a survival advantage, according to several retrospective analyses. However, few data are available regarding the morbidity of radical prostatectomy in the metastatic setting. We addressed intra- and postoperative complications of CRP relative to radical prosta...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Ilaria Cavarretta, Nicasio Mancini, Andrea Salonia
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Atiqullah Aziz, Matthias May, Oliver W. Hakenberg, Sabine D. Brookman-May
Source: European Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONThe significance of BDR for pT2 or higher advanced GBC without biliary infiltration was equivocal because the patients received no survival benefit by undergoing BDR.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 20 July 2018Source: European Journal of Surgical OncologyAuthor(s): Maria Anna Smolle, Michael Parry, Lee Jeys, Seggy Abudu, Robert GrimerAbstractObjectivesSynovial sarcoma, a distinct subtype of soft tissue sarcomas (STS), is typically found in young patients. Long history of symptoms and heterogeneous clinical presentation sometimes delays diagnosis. Children have been reported to have a better prognosis than adults in some series.The main emphasis of this study was to determine differences between children and adults and to investigate prognostic factors regarding cancer specific survi...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionTPE is an invasive treatment for rectal cancer with high 30-day mortality in elderly patients. Oncological outcomes are similar in elderly and younger patients. Therefore, TPE should not be withheld because of high age only, but careful patient selection is needed.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsThe nomograms were able to more accurately predict 3- and 5-year OS and CSS of patients with GISTs than were existing models.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Sanjeevan Muruganandan, Maree Azzopardi, Deirdre B Fitzgerald, Ranjan Shrestha, Benjamin C H Kwan, David C L Lam, Christian C De Chaneet, Muhammad Redzwan S Rashid Ali, Elaine Yap, Claire L Tobin, Luke A Garske, Phan T Nguyen, Christopher Stanley, Natalia D Popowicz, Christopher Kosky, Rajesh Thomas, Catherine A Read, Charley A Budgeon, David Feller-Kopman, Nick A MaskellSummaryBackgroundIndwelling pleural catheters are an established management option for malignant pleural effusion and have advantages over talc slurry pleurode...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
The objective of this study was to examine the usefulness of these less invasive small-bore aspiration catheters for drainage of pneumothorax.MethodsBaseline characteristics and laboratory test data at admission of 70 patients who were admitted to and underwent drainage treatment for pneumothorax at our hospital between April 2011 and February 2017 were retrospectively reviewed based on their medical records. The primary endpoints were factors associated with drainage treatment failure, and baseline characteristics and laboratory test data were compared between those treated with a small-bore aspiration catheter and those ...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
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