Inflammation, circadian rest-activity rhythms, and behavioral sequelae of chronic graft-versus-host disease

Publication date: November 2017 Source:Brain, Behavior, and Immunity, Volume 66, Supplement Author(s): E.S. Costanzo, M.B. Juckett, C.L. Coe, D.A. Dickson, K. Morris, P. Hematti, M.E. Rumble Chronic graft-versus-host-disease (cGVHD) is a common complication of hematopoietic stem cell transplantation that involves alloegeneic and autoimmune dysregulation affecting multiple organ systems. We hypothesized that disrupted circadian rest-activity rhythms and inflammation contribute to co-occurring behavioral symptoms in this population. Adults with cGVHD (N=55) wore a wrist actigraph for 7days, provided a blood sample, completed self-report measures of depression (IDAS), fatigue (FSI), and cognition (PROMIS), and underwent clinical evaluation. Rest-activity indices (mesor, amplitude, acrophase) were derived from actigraphy. Cytokines and chemokines relevant to cGVHD (IL-6, IL-8, TNF α , MIF, MCP-1, MIP-1 alpha) were measured with multiplex detection. After covarying for disease severity and age, participants with less optimal rest-activity patterns, including less overall activity (mesor) and less distinction between daytime and nighttime activity (amplitude), reported more severe depression ( β =−.372, −.296), fatigue ( β =-.237, −.314), and cognitive dysfunction ( β =.331, .440) and had poorer physician-rated performance status ( β =.340, .383); all p < .05. Higher circulating IL-8 and MIP-1 alpha were associated with greater depression ( β =.304...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research