Use of reflectance confocal microscopy to evaluate 5 ‐fluorouracil 0.5%/salicylic acid 10% in the field‐directed treatment of subclinical lesions of actinic keratosis: subanalysis of a Phase III, randomized, double‐blind, vehicle‐controlled trial

ConclusionTo the best of our knowledge, this is the first randomized, vehicle‐controlled study investigating 5‐FU 0.5%/salicylic acid 10% treatment for subclinical AK lesions. The present data suggest some treatment efficacy for subclinical AK lesions detected using RCM. However, this subanalysis was not sufficiently powered and should be reproduced in a larger, subsequent cohort.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fjdv.14611

Source: Journal of the European Academy of Dermatology and Venereology - October 19, 2017 Category: Dermatology Authors: M. Ulrich, U. Reinhold, M. Falqu és, R. Rodriguez Azeredo, E. Stockfleth Tags: Original Article Source Type: research