Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differentiated thyroid cancer: a randomized-controlled trial

This study aimed to examine the radioprotective effect of vitamin E on salivary glands after radioactive iodine (131I) therapy in patients with differentiated thyroid cancer. Patients and methods: Eighty-two patients with differentiated thyroid cancer were enrolled in this study. They were divided randomly into four groups (control group: 22 cases, group A: 23 cases, group B: 22 cases, and group C: 15 cases) before postsurgical ablation therapy with 100 mCi 131I. The patients in groups A, B, and C received vitamin E 100, 200, and 300 mg/day orally, respectively, for a duration of 1 week before to 4 weeks after 131I therapy. Salivary gland function was assessed using salivary gland scintigraphy immediately before and 6 months after 131I therapy. Uptake fraction (UF), uptake index (UI), excretion fraction (EF), and excretion ratio (ER) of each salivary gland were measured and compared. Results: On comparison between before and after 131I therapy in the control group, there was a significant decrease in UF of both right and left parotid glands (all P
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research