Effect of inhalational anesthetics on acute kidney injury.
EFFECT OF INHALATIONAL ANESTHETICS ON ACUTE KIDNEY INJURY.
Acta Clin Croat. 2016 09;55(3):464-8
Authors: Bublić MM, Tonković D, Sakan S, Misir A, Pavlović DB
Abstract
Acute kidney injury (AKI) is a serious complication associated with increased
morbidity and mortality. Total incidence of AKI in hospitalized patients is 1%-5%. As many as 30%
of these patients develop AKI in the perioperative period, which is associated with anesthesia and
surgery. Despite scientific advances and improved surgery techniques, as well as treatment in intensive
care units, no significant decrease in AKI incidence has been achieved. To change this outcome, it is
important to identify patients at risk of AKI and prevent its occurrence. Correct selection of anesthetic
drugs during general anesthesia, adjusted to the individual needs of patients, also influences the
overall outcome of treatment. Nowadays, inhalational anesthetics are not considered nephrotoxic. The
more so, inhalational anesthetics have a strong and direct protective effect on many organs through
preconditioning and postconditioning. New studies have shown that sevoflurane diminishes ischemia/
reperfusion kidney injury and has an anti-inflammatory effect, thus having the potential to reduce the
occurrence of AKI. Given the incidence of AKI in the perioperative period, as well as new findings
about anesthetics, the issue of anesthetic selection during general anesthesia might be of crucial ...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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