Non-coding RNA expression and targeted next-generation sequencing distinguish Tubulocystic Renal Cell Carcinoma (TC-RCC) from other renal neoplasms

Tubulocystic renal cell carcinoma (TC-RCC) is a rare recently described renal neoplasm characterized by gross, microscopic and immunohistochemical differences from other renal tumor types that was recently classified as a distinct entity. However, this distinction remains controversial particularly as some genetic studies suggest a close relationship with papillary renal cell carcinoma (PRCC). The molecular basis of this disease remains largely unexplored. We therefore performed non-coding (nc)RNA/miRNA expression analysis and targeted next-generation sequencing mutational profiling on 13 TC-RCC cases (11 pure, two mixed TC-RCC/PRCC) and compared with other renal neoplasms.

Source: Journal of Molecular Diagnostics - October 19, 2017 Category: Pathology Authors: Charles H. Lawrie, Mar ía Armesto, Marta Fernandez-Mercado, María Arestín, Lorea Manterola, Ibai Goicoechea, Erika Larrea, María M. Caffarel, Angela M. Araujo, Carla Sole, Maris Sperga, Isabel Alvarado-Cabrero, Michal Michal, Ondrej Hes, José I. Lóp Tags: Regular Article Source Type: research