Test genetici per pazienti con carcinoma metastatico mammario

Dott.ssa Fiorana Morgillo, specialista in cancro al polmone presso lOspedale San Raffaele (Milano) Author: patientpower Added: 10/19/2017
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts

Related Links:

Authors: Ahmed SR, Petersen E, Patel R, Migden MR Abstract INTRODUCTION: In September of 2018, the United States Federal Drug Administration (FDA) approved cemiplimab-rwlc (Libtayo) for advanced cutaneous squamous cell carcinoma (CSCC). Cemiplimab is an intravenous human monoclonal antibody directed against programmed cell death-1 receptor (PD-1). Cemiplimab blocks T-cell inactivation and enhances the immune system's anti-tumor response. Areas Covered: We review CSCC and the studies leading to cemiplimab's approval, including common side effects and safety issues experienced during the clinical trials. Expert Opini...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Publication date: Available online 17 September 2019Source: Genes &DiseasesAuthor(s): Prasanna.K. Santhekadur, Divya.P. KumarAbstractRNA-induced silencing complex (RISC) is one of the basic eukaryotic cellular machinery which plays a pivotal role in post-transcriptional gene regulation. Discovery of miRNAs and their role in gene regulation have changed the course of modern biology. The method of gene silencing using small interfering RNAs and miRNAs has become major tool in molecular biology and genetic engineering. Hepatocellular carcinoma (HCC) is a very common malignancy of liver in developing countries and due to v...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
We present a 66 year-old-man that was referred to our center after the casual finding of a renal mass. With a suspected diagnosis of a renal cell carcinoma, a partial nephrectomy was performed. The histological study revealed the final diagnosis of a benign renal schwannoma.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 September 2019Source: Urology Case ReportsAuthor(s): Lim HC, Khong TL, Ong TA, Roslani AC, Ang CWAbstractBladder perforation secondary to transurethral resection of bladder tumour (TURBT) increases the risk of tumour seeding and eventual extravesicle metastasis. Here we presented a case where a patient with localised bladder tumour was initially managed with repeated TURBT for tumour recurrence. Subsequently he was found to have extravesicle pelvic metastasis. This was likely secondary to microperforation of bladder and tumour seeding. Microscopic bladder perforation is difficult to di...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
This report presents a case of a 39-years old female presented with incidentally discovered renal mass in a crossed fused ectopia. Careful preoperative planning and meticulous delineation of renal vasculature were performed to avoid unpredicted anatomy. Nephron-sparing surgery with preservation of the normal-functioning moiety was performed with uneventful postoperative course. These clinical, morphological and immune-histochemical features will be presented with a review of the current literature.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionDespite the current lack of evidence supporting the use of CRS and HIPEC in the curation of PC of pancreatic origin, this case report highlights the importance of patient selection in determining suitability for CRS. In the presence of positive prognostic factors and favorable tumor histology, CRS and HIPEC is a potential curative procedure that could be offered to highly selected patients presenting with PC from a primary pancreatic malignancy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 17 September 2019Source: Journal of Advanced ResearchAuthor(s): Peio Errarte, Gorka Larrinaga, José I. LópezAbstractCancer-associated fibroblasts (CAF) are a cellular compartment of the tumor microenvironment with critical roles in tumor development. Fibroblast activation protein-α (FAP) is one of the proteins expressed by CAF and its immunohistochemical detection in routine practice is associated with tumor aggressiveness and shorter patient survival. For these reasons, FAP seems a good prognostic marker in many malignant neoplasms, including renal cell carcinoma (RCC...
Source: Journal of Advanced Research - Category: Research Source Type: research
Condition:   Basal Cell Carcinoma Intervention:   Other: individualized risk assessment Sponsor:   University of Wisconsin, Madison Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Hepatocellular Carcinoma;   Hepatoblastoma Interventions:   Genetic: TEGAR T cells;   Drug: Cytoxan;   Drug: Fludarabine Sponsors:   Baylor College of Medicine;   Texas Children's Hospital;   The Methodist Hospital System Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Based on multidisciplinary discussions with colleagues from breast surgical oncology, medical oncology, and plastic surgery, our recommendation was to proceed with local excision and sentinel lymph node biopsy followed by comprehensive radiation therapy to the chest wall and undissected regional nodal basins. Surgical pathology demonstrated invasive ductal carcinoma with 1.2 cm of residual disease and 30% tumor cell viability, negative margins, and no lymphovascular invasion. A sentinel lymph node biopsy was attempted, but no sentinel node was identified.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
More News: Cancer & Oncology | Carcinoma | Genetics