Inhibition of Yeast ‐to‐Filamentous Growth Transitions in Candida albicans by a Small Molecule Inducer of Mammalian Apoptosis

In this study, we have screened additional inducers of mammalian apoptosis and identified BH3I‐1, as well as several structural derivatives of BH3I‐1, that act as specific inhibitors of morphogenesis under a variety of environmental conditions. Chemical epistasis experiments suggest that BH3I‐1 acts downstream of the hypha‐specific gene regulators Rfg1, Nrg1 and Ume6.
Source: Yeast - Category: Molecular Biology Authors: Tags: RESEARCH ARTICLE Source Type: research