Evaluation of a disease risk index for adult patients undergoing umbilical cord blood transplantation for haematological malignancies

Summary A disease risk index (DRI) has been defined for stratifying heterogeneous cohorts of patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). This index defines 4 distinct groups with different outcomes, dividing patients by disease type and status and considering cytogenetics for acute myeloid leukaemia and myelodysplastic syndromes (MDS). Recently, the DRI has been refined to include rare diseases and improve MDS stratification by blast percentage and response to prior therapy. Previous reports on DRI include only a small number of UCBT recipients. The current study aims to determine the applicability of the DRI for patients undergoing unrelated cord blood transplantation (UCBT). We retrospectively analysed 2530 adults receiving UCBT between 2004 and 2014. Diagnosis was acute leukaemia (AL) in 66% of the cases. Overall survival (OS) at 2 years was 56 ± 3% for patients with low DRI (n = 352), 46 ± 1% for intermediate DRI (n = 1403), 28 ± 2% for high (n = 489) and 20 ± 4% for very high DRI (n = 109) (P 
Source: British Journal of Haematology - Category: Hematology Authors: Tags: Research Paper Source Type: research

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Source: Pediatric Neurosurgery - Category: Neurosurgery Source Type: research
Jun Hu, Lingli Chen, Yimei Tang, Chunlin Xie, Baoyang Xu, Min Shi, Wenyong Zheng, Shuyi Zhou, Xinkai Wang, Liu Liu, Yiqin Yan, Tao Yang, Yaorong Niu, Qiliang Hou, Xiaofan Xu, Xianghua Yan
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Authors: Bodilsen J, Brouwer MC, Nielsen H, van de Beek D Abstract INTRODUCTION: Brain abscess is an uncommon and potentially life-threatening infection of the CNS that can be caused by a range of different pathogens including bacteria, fungi and parasites. A multidisciplinary approach is important and anti-infective treatment remains crucial. Here, we review anti-infective treatment of brain abscess. Areas covered: We used the terms '(Brain abscess[ti] AND (antibiotic* OR treatment)) NOT case report'), to conduct a search in the PubMed. Additional papers were identified by cross-reference checking and by browsing ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Authors: Pleines I, Cherpokova D, Bender M Abstract Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo fission to release platelets. Defects in platelet production can lead to a low platelet count (thrombocytopenia) with increased bleeding risk. Rho GTPases comprise a family of small signaling G proteins that have been shown to be master regulators of the cytoskeleton controlling many aspects of intracellular process...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Conditions:   Clostridium Difficile Infection Recurrence;   Clostridium Difficile Infection Intervention:   Procedure: Fecal Microbiota Transplantation Sponsor:   University of Massachusetts, Worcester Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Advanced Lung Disease;   Lung Transplant;   Extracorporeal Membrane Oxygenation Interventions:   Device: MRP and NMES(neuromuscular electric stimulation);   Other: Standard of Care Sponsor:   University of Maryland Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Idiopathic Pulmonary Fibrosis;   Lung Transplant; Complications Interventions:   Drug: Nintedanib;   Drug: Placebo Oral Tablet Sponsors:   Temple University;   Boehringer Ingelheim Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Southern Medical Journal - Category: Journals (General) Tags: South Med J Source Type: research
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