Niacin, Heart Disease And The Fallacy That All Older Drugs Are Safe And Effective

The bottom line is that no drug is perfect; all have side-effects. There is no guarantee that either the age or newness of a drug will confer better safety or efficacy. One thing you can be certain of, however, is that drugs approved today have been studied in greater depth than ever before.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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Conclusion: In patients with prosthetic valve replacement, anticoagulant therapy with VKA seems to be an effective option. The role for non-VKA oral anticoagulants in the setting of prosthetic valve replacement has yet to be established. Furthermore, whether the novel oral anticoagulants are safe and efficacious in patients after placement of a bioprosthetic valve remains unanswered. PMID: 30341847 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: While evaluating syncope most often the battery of investigations does not lead to any conclusive diagnosis. There was male predominance in presentation. Out of 50 patients 10% had cardiogenic, 20% had neurocardiogenic and in 70% diagnosis was not established. Only 20% had HUTT positive. Echocardiography is the investigation of choice in patients of valvular heart disease. A thorough clinical evaluation is must, investigations are of limited value. PMID: 30341843 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionIn this population, there were no differences in appropriate shocks or all-cause mortality in the two groups.ResumoIntrodução e objectivoO benefício do desfibrilhador implantável está bem demonstrado nos doentes com cardiopatia isquémica. No entanto, a evidência deste benefício é menos robusta em doentes com cardiopatia não isquémica. Pretendeu-se determinar se os doentes com cardiopatia não isquémica apresentavam a mesma incidência de choque apropriado e mortalidade total, comparativamente àqueles com cardiopat...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity. RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes https://www.fightaging.org/archives/...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Long time readers know that I often write about exercise and fitness.  Over the past 3 years I have written often about Orange Theory Fitness.  OTF focuses on high intensity interval training (cardio) complemented by strength work.  Working out regularly makes me feel better in many ways, and I would do it for a variety of reason, but this new article adds even more fuel to my OTF fire.  Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing.   The article is free.  CNN has a great article explaining the study – ...
Source: DB's Medical Rants - Category: Internal Medicine Authors: Tags: Medical Rants Source Type: blogs
Authors: Kim DH, Kang DH Abstract The burden of valvular heart disease (VHD) is increasing with age, and the elderly patients with moderate or severe VHD are notably common. When to operate in asymptomatic patients with VHD remains controversial. The controversy is whether early surgical intervention should be preferred, or a watchful waiting approach should be followed. The beneficial effects of early surgery should be balanced against operative mortality and long-term results. Indications of early surgery in each of the VHD will be discussed in this review on the basis of the latest American and European guidelin...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Congenital Heart Disease, EarlyView.
Source: Congenital Heart Disease - Category: Cardiology Authors: Source Type: research
Congenital Heart Disease, EarlyView.
Source: Congenital Heart Disease - Category: Cardiology Authors: Source Type: research
Congenital Heart Disease, EarlyView.
Source: Congenital Heart Disease - Category: Cardiology Authors: Source Type: research
This article is to investigate the association between C677T polymorphism of 5, 10-methylenetetrahydrofolate (MTHFR) gene and congenital heart defects (CHD). Two hundred thirty-five nuclear families (father, mother and child) with CHD were enrolled in the study (experimental group), and two hundred thirty-five healthy nuclear families were selected as a control group. Under the case-control study, the C677T polymorphism of MTHFR gene was detected with polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. The distribution of genotype frequency in the CHD group and control group were analyzed...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
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