Niacin, Heart Disease And The Fallacy That All Older Drugs Are Safe And Effective

The bottom line is that no drug is perfect; all have side-effects. There is no guarantee that either the age or newness of a drug will confer better safety or efficacy. One thing you can be certain of, however, is that drugs approved today have been studied in greater depth than ever before.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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You likely know that after several years, type 2 diabetes commonly leads to serious complications. Common complications include diabetic retinopathy, neuropathy, kidney disease and kidney failure, heart disease, and increased potential for dementia, not to mention an average of 8 years lost off your life. Prescription drugs have only a modest effect on reducing risk, sometimes none, for these complications. But there is a way to dramatically reduce potential for diabetic complications: become a NON-diabetic. We’ve done it many times, as have others. But you cannot accomplish this by just following conventional diets...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates diabetes undoctored Weight Loss wheat belly Source Type: blogs
(MedPage Today) -- How many push-ups a man can do may predict his heart disease risk, Harvard study shows
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news
Authors: Peng J, Xiang Y Abstract Expression and clinical significance of CD69 and early growth response (EGR1) in plasma of patients with coronary heart disease (CHD) were investigated. A total of 194 patients with CHD and 130 healthy subjects, respectively, were selected as CHD and control group, clinical data were collected and coronary angiography was performed. RT-qPCR was used to detect the expression of EGR1. Flow cytometry was used to detect the expression level of CD69 and the receiver operating characteristic curve was used to analyze the values of relative expression of CD69 and EGR1. The relative expres...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Liu W, Wang T, Sun P, Zhou Y Abstract Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats. Exp Ther Med. 2019 Mar;17(3):1587-1592 Authors: Zheng J, Zhang S, Wang T Abstract Expression changes of Notch-1 and nuclear factor-κB (NF-κB) in cardiomyocytes from coronary heart disease (CHD) rats were investigated. The CHD model established by high-fat diet in 48 clean SD rats was set as the observation group, and another 48 healthy rats routinely fed were the control group. Rats were sacrificed on the 1st, 3rd, 7th, and 14th days after successful modeling. The rat myocard...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: Available online 22 February 2019Source: Pharmacology &TherapeuticsAuthor(s): I. Elgenaidi, J.P. SpiersAbstractPhosphoprotein phosphatases are of growing interest in the pathophysiology of many diseases and are often the neglected partner of protein kinases. One family member, PP2A, accounts for dephosphorylation of ~55-70% of all serine/threonine phosphosites. Interestingly, dysregulation of kinase signalling is a hallmark of many diseases in which an increase in oxidative stress is also noted. With this in mind, we assess the evidence to support oxidative stress-mediated regulation of the PP2A syste...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Interest in the anatomy of the interatrial septum (IAS) and its adjoining atrioventricular (AV) junction has risen enormously in the past two decades with the simultaneous evolution of left-sided percutaneous structural heart disease and complex electrophysiologic procedures. These procedures require, in fact, a direct route to the left atrium through the IAS. Thus, a thorough understanding of the complex anatomy of the IAS and AV junction is essential for performing a safe and effective transseptal puncture.
Source: Journal of the American Society of Echocardiography - Category: Cardiology Authors: Source Type: research
ConclusionWe have shown that it is possible to perform detailed 2D and 3D studies using iuMR that allow thorough investigation of all intracranial compartments in fetuses with CHD in a clinically appropriate scan time. Those fetuses have a high risk of structural brain abnormalities and smaller brain volumes even when brain ultrasonography is normal.
Source: Neuroradiology - Category: Radiology Source Type: research
(Natural News) In a new study that was published in the Journal of Hepatology, researchers were able to surmise that nonalcoholic fatty liver disease (NAFLD) is not only associated with hepatocellular carcinoma (HCC), but also to cancers that have nothing to do with the liver, such as colorectal and breast cancers. “NAFLD is a very...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Condition:   Congenital Heart Disease Intervention:   Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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