Evaluation of the Antiplasmodial Properties of Namibian Medicinal Plant Species, Moringa ovalifolia

Conclusion: M. ovalifolia extracts exhibited moderate antiplasmodial properties in vitro and have potential as antimalarials. These findings provide a basis for further investigation into their phytochemistry as well as in vivo studies on their safety and efficacy to support their use as an alternative treatment for malaria.
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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(Natural News) Summer usually means going camping or hiking, but pesky mosquitoes can take the fun out of these activities. (h/t to TheSurvivalistBlog.net) Aside from feeding on your blood and causing itchy bites, mosquitoes also spread diseases like encephalitis, malaria, and West Nile fever. Only female mosquitoes require blood and they are attracted to body heat,...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusion: The 1.3% prevalence of Plasmodium malaria parasites in screened donor blood units represents risk of malaria blood transfusion transmitted infection and a pool of community transmittable malaria infections, respectively. PMID: 30112007 [PubMed]
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
Abstract DHFR from Pf is a known target for malaria. There is a continued effort for the design and development of the potent inhibitor for PfDHFR in the control of malaria. Therefore it is of interest to screen PfDHFR with the derivatives of Pyrimethamine. The results show that the compound CID 10476801 has lowest docked energy (-11.48 kcal/mol) with protein likely to be a drug candidate, probably inhibiting PfDHFR structure. Residues of PfDHFR protein involved in the formation of hydrogen bonds with compound CID 10476801 are confirmed to be ASP54. The findings provide new insights into development of potent chem...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
This study investigated the prevalence of haplotypes of the Pfdhps, Pfdhfr, Pfcrt, Pfmdr1 and PfK13 resistance markers in isolates from asymptomatic patients from the Republic of the Congo following implementation of artemisinin based-combination therapy (ACT).MethodsPeripheral blood was collected from asymptomatic children in 2010 and 2015 from Brazzaville in the south and in 2013 in the north of the Congo. Genotypes of Pfmdr1, Pfcrt, Pfdhps, Pfdhfr and PfK13 were assessed by PCR.ResultsChildren from 2010 were younger than those from 2015 (mean age 5.38 years vs. 8.67 years; P = 0.003). The main Pfcrt haplotype ...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This study assessed the influence of physical characteristics of houses and surroun...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Much of the extensive research regarding transmission of malaria is underpinned by mathematical modelling. Compartmental models, which focus on interactions and transitions between population strata, have been...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Vivax malaria is a leading public health concern worldwide. Due to the high prevalence of Duffy-negative blood group population, Plasmodium vivax in Africa historically is less attributable and remains a neglecte...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
150 years after Semmelweis advised fellow physicians to sanitize their hands to mitigate the effect of infections, the maintenance of hygiene is still a widespread problem in hospitals and the source of healthcare-associated infections. Now, technological solutions line up against microorganisms, bacteria, and fungi. Here are a few examples. 1 in 9 in-patients will die due to infection According to the US Center for Disease Control, studies show that on average, healthcare providers clean their hands less than half of the times they should. This significantly contributes to the spread of healthcare-associated infections (H...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Healthcare Design Medical Professionals Policy Makers clean digital digital health future HAI healthcare-associated infection hygiene Medicine robot robotics sensors technology trackers wearable Source Type: blogs
This study aimed to assess patients' knowledge of antimalarial treatment (ACT) and its association with patient adherence. A descriptive cross-sectional study design was employed in this study. Data were collected from April to May 2017. Both descriptive and inferential statistics in the form of frequencies, percentages, mean values, standard deviations, and Pearson's chi-square test were generated by use of Microsoft excel spreadsheet and IBM Statistical Package for Social Sciences (SPSS) version 23. The average age of the respondents surveyed for this study was 42.27 ± 11.09. Adherence level to ACT was 47%. The re...
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
(University of Copenhagen The Faculty of Health and Medical Sciences) In a spectacular new study, researchers from the University of Copenhagen have discovered a method of diagnosing a broad range of cancers at their early stages by utilising a particular malaria protein, which sticks to cancer cells in blood samples. The researchers hope that this method can be used in cancer screenings in the near future.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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