Evaluation of the Antiplasmodial Properties of Namibian Medicinal Plant Species, Moringa ovalifolia

Conclusion: M. ovalifolia extracts exhibited moderate antiplasmodial properties in vitro and have potential as antimalarials. These findings provide a basis for further investigation into their phytochemistry as well as in vivo studies on their safety and efficacy to support their use as an alternative treatment for malaria.
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Publication date: Available online 7 December 2018Source: International Journal of PharmaceuticsAuthor(s): Maria Manconi, Maria Letizia Manca, Elvira Escribano-Ferrer, Elisabet Martí Coma-Cros, Arnau Biosca, Elena Lantero, Xavier Fernàndez-Busquets, Anna Maria Fadda, Carla CaddeoAbstractIn this paper, nutriosomes (phospholipid vesicles associated with Nutriose® FM06) were modified to obtain new systems aimed at enhancing the efficacy of curcumin in counteracting malaria infection upon oral administration. Eudragit® L100, a pH-sensitive co-polymer, was added to these vesicles, thus obtaining eudragit-n...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Condition:   Plasmodium Falciparum Malaria Interventions:   Drug: Artemether-lumefantrine;   Drug: Artesunate + Amodiaquine Sponsors:   Professor Anders Björkman;   Zanzibar Malaria Control Programme Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Amaya Ortega-Pajares, Stephen J. Rogerson
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Durand S, Lachira-Alban A, Sánchez CC Abstract At the end of the 90s in Peru, after determining the resistance to antimalarial drugs, a change in antimalarial treatment schemes was decided; this change included the combined therapy for P. falciparum, mefloquine/artesunate in the Amazon region, and sulfadoxine pyrimethamine/artesunate in the North coast. After two decades, and aimed at assessing the impact of these schemes on the malaria endemic, a review was conducted of malaria reports in three departments accounting for more than 70% of cases reported in the country. The major impact of the sulfad...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
CONCLUSIONS: There are high levels of knowledge about malaria; however, the care of the mosquito nets does not follow the recommendations to increase their useful life, therefore, specific social strategies are required for each department. PMID: 30517497 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
CONCLUSIONS.: Lack of opportunity in the diagnosis was identified in 44% of the visited sites and deficiencies in the quality component of the border diagnostic network. PMID: 30517496 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
ConclusionsPRRD1 and estimates of PCT using PRRD1 linear regression equation of PRRD1 and PCT can be used in therapeutic efficacy studies.Trial registrationPan African Clinical Trial Registration PACTR201709002064150, 1 March 2017,http://www.pactr.org
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
In malaria endemic countries, asymptomatic cases constitute an important reservoir of infections sustaining transmission. Estimating the burden of the asymptomatic population and identifying areas with elevate...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
In Tanzania, the roles of men and women are classified based on the local cultural context. While men are usually the breadwinners, women are traditionally responsible for most domestic chores. Particularly fo...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Ensuring malaria commodity availability at health facilities is a cornerstone of malaria control. Since 2013, the Guinea National Malaria Control Programme has been routinely collecting data on stock levels of...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
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