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Brothers Thrive After Lung Transplants at Duke

Treatment TermsPulmonary fibrosis and interstitial lung diseaseLung transplantPulmonary rehabilitation Author Karen Doss Bowman Overview U.S. Air Force veteran Michael Bonnette and his brother Robert, a volunteer firefighter, are used to saving the lives of others. After developing pulmonary fibrosis, they turned to Duke University Hospital for double lung transplants because of its short wait times and pulmonary rehab program. Now, a few years later, the brothers are back to their active lifestyles. Hero Image20170927.bonnettes.web_.01.jpg Preview Image Content Blocks Section Features Images/Media Text Content Section Features Images/Media Text Content Section Features Images/Media Text Content Header Possible Genetic Predisposition ContentThe cause of pulmonary fibrosis is often unknown and most people do not have a clear family history of the disease, explained Duke pulmonologistJohn Reynolds, MD. But there are rare circumstances of familial pulmonary fibrosis, in which more than one member of the same family will develop the disease.“There can be a genetic predisposition for pulmonary fibrosis, and that’s a possibility in this situation,” Dr. Reynolds said. “However, both Michael and Robert were exposed to environmental factors as well. It’s hard to know how much of their condition was triggered by inhaling something versus another factor. Without other generational family members affected, it’s hard to implicate a fa...
Source: dukehealth.org: Duke Health News - Category: Consumer Health News Authors: Source Type: news

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Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 75-year-old man is seen for routine follow-up for very severe COPD. He has constant dyspnea and air hunger and spends most of the day in a chair. He has had no change in baseline cough and sputum production. He has had multiple COPD exacerbations that required ICU admission and intubation. He has not benefited from pulmonary rehabilitation in the past. He quit smoking 3 years ago. His medical history is also notable for hypertension, type 2 diabetes mellitus, and a myocardial infarction 3 years ago. Hi...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Palliative Care Pulmonology Source Type: blogs
Purpose of review Lung transplantation offers an effective treatment modality for patients with end-stage chronic obstructive pulmonary disease (COPD). The exact determination of when to refer, list, and offer transplant as well as the preferred transplant procedure type remains unclear. Additionally, there are special considerations specific to patients with COPD being considered for lung transplantation, including the implications of single lung transplantation on lung cancer risk, native lung hyperinflation, and overall survival. Recent findings The International Society for Heart and Lung Transplantation's most re...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Manish Joshi and Basil Varkey Source Type: research
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book's index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 1...
Source: Specified Life - Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
ConclusionsMycobacterium abscessus infection in LTR is rare and can lead to severe complications. Eradication is difficult and usually requires prolonged combination antibiotic therapy and occasionally surgical management.This article is protected by copyright. All rights reserved.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Tags: Original Report Source Type: research
Purpose of review There has been expanding interest in and use of extracorporeal support in respiratory failure concurrent with technological advances and predominantly observational data demonstrating improved outcomes. However, until there is more available data from rigorous, high-quality randomized studies, the future of extracorporeal support remains uncertain. Recent findings Outcomes for patients supported with extracorporeal devices continue to show favorable trends. There are several large randomized controlled trials that are in various stages of planning or completion for extracorporeal membrane oxygenation...
Source: Current Opinion in Critical Care - Category: Nursing Tags: RESPIRATORY SYSTEM: Edited by Michael Quintel and Luciano Gattinoni Source Type: research
I’ve had asthma and chronic lung disease since I was very young. I had to use everything — from my head to my toes — to help me breathe. I remember being able to hear myself wheezing, to feel my lungs rattling. I had marks all over my face from my oxygen mask. I thought I would never be clear of mucus and never be able to walk without being out of breath. All I ever wanted was to breathe. I spent so much energy trying to breathe that I didn’t have much left for eating, so I was really skinny. I spent a lot of time in a wheelchair. When I was able to walk, it would be for short distances and my shoul...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories chronic lung disease double lung transplant Francis Fynn-Thompson Gary Visner Lung Transplant Program Pediatric Transplant Center (PTC) Source Type: news
Abstract BACKGROUND The aim of this study was to investigate serum concentrations of visfatin, irisin, and omentin in patients with end-stage lung diseases (ESLD) before and after lung transplantation (LTx) and to find relationship between adipokines levels and clinical outcomes. MATERIAL AND METHODS Fourteen consecutive lung transplant recipients (six males and seven females; age 32.0±14.2 years; body mass index (BMI) 21.8±5.3 kg/m²) who underwent lung transplantation with initial diagnosis of respiratory failure due to cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), idiopat...
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Authors: Kahn N, Andrianopoulos V, Mekov E, Herth FJF Abstract This review highlights a selection of abstracts from the 2017 ERS International Congress in Milan presented by the clinical assembly's groups of interventional pulmonology, general practice and primary care and rehabilitation and chronic care. Attention is brought to the increasing burden of disease of COPD and end-stage emphysema patients in China. The considerable efforts of Chinese pulmonary centers to conduct multicenter, randomized and controlled trials, investigating the possibilities of bronchoscopic lung volume reduction is underlined in the rev...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Purpose of review There has been expanding interest in and use of extracorporeal support in respiratory failure concurrent with technological advances and predominantly observational data demonstrating improved outcomes. However, until there is more available data from rigorous, high-quality randomized studies, the future of extracorporeal support remains uncertain. Recent findings Outcomes for patients supported with extracorporeal devices continue to show favorable trends. There are several large randomized controlled trials that are in various stages of planning or completion for extracorporeal membrane oxygenation...
Source: Current Opinion in Critical Care - Category: Nursing Tags: RESPIRATORY SYSTEM: Edited by Michael Quintel and Luciano Gattinoni Source Type: research
Rationale: Patients with severe COPD and/or emphysema have a distinct pulmonary inflammome characterized by a different regulation of the immune response that should be better explored integrating the results of RNA expression with epigenetic changes.Objective: To compare the pulmonary mRNA and miRNA of COPD patients with and without emphysema (CT scan) and various disease severity.Methods: Lung tissue from 70 former smokers with COPD was obtained from individuals undergoing thoracic resectional surgery (mostly because of lung cancer) or lung transplantation explants. Total RNA was extracted, small RNA libraries were const...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular Pathology and Functional Genomics Source Type: research
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