Brothers Thrive After Lung Transplants at Duke
Treatment TermsPulmonary fibrosis and interstitial lung diseaseLung transplantPulmonary rehabilitation Author Karen Doss Bowman Overview U.S. Air Force veteran Michael Bonnette and his brother Robert, a volunteer firefighter, are used to saving the lives of others. After developing pulmonary fibrosis, they turned to Duke University Hospital for double lung transplants because of its short wait times and pulmonary rehab program. Now, a few years later, the brothers are back to their active lifestyles. Hero Image20170927.bonnettes.web_.01.jpg Preview Image Content Blocks Section Features Images/Media Text Content Section Features Images/Media Text Content Section Features Images/Media Text Content Header Possible Genetic Predisposition ContentThe cause of pulmonary fibrosis is often unknown and most people do not have a clear family history of the disease, explained Duke pulmonologistJohn Reynolds, MD. But there are rare circumstances of familial pulmonary fibrosis, in which more than one member of the same family will develop the disease.“There can be a genetic predisposition for pulmonary fibrosis, and that’s a possibility in this situation,” Dr. Reynolds said. “However, both Michael and Robert were exposed to environmental factors as well. It’s hard to know how much of their condition was triggered by inhaling something versus another factor. Without other generational family members affected, it’s hard to implicate a fa...
In this study, we sought to further characterize ILC2s in the kidney, their location within this organ and determine their functional role in IRI using a loss-of-function approach. Here, we found that kidney ILC2s constitutively express IL-5 and are primarily located in close proximity to the renal vasculature, within the adventitia. Additionally, we demonstrate that a reduction, deficiency or depletion of ILC2s had minimal impact on the severity of IRI. Whilst activation of ILC2s and the associated amplification of local type 2 immunity has been previously shown to reduce the deleterious consequences of AKI, our results r...
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Conditions: Advanced Lung Disease; COPD; ILD Intervention: Sponsor: Klinikum Berchtesgadener Land der Schön-Kliniken Recruiting
Conclusions. The BLTx recipients with CF had inferior survival and longer ICU LOS when receiving organs from donors 55 years or older. Recipients with COPD, ILD, or in the “other” group did not have inferior survival in multivariate models.
Pentraxin-3 (PTX3) polymorphisms influence the risk of invasive pulmonary aspergillosis (IPA) in chronic obstructive pulmonary disease patients, hematopoietic stem cell recipients and solid organs recipients. Therefore, we aimed to investigate this association in a large lung transplant population.
Single lung transplants (SLT) for chronic obstructive pulmonary disease (COPD) are characterized by hyperinflation of the contralateral native lung which may be more pronounced in single left lung transplants. Although single and double lung transplant (DLT) outcomes have been investigated, single right and left lung transplants have never been rigorously compared to evaluate disease specific differences.
Although COPD patients account for a large proportion of lung transplants, whether double lung transplantation (DLT) versus single (SLT) improves survival for COPD patients is not well established.
The objective of this survey was to assess the practices of international lung transplant (LTx) centers, pertaining to the testing for, and replacement of, AAT in patients with AATD.
Irisin is a skeletal muscle cell-derived myokine associated with physical activity. Recently, decreased serum irisin levels have been shown to cause alveolar epithelial apoptosis resulting in lung emphysema in patients with chronic obstructive pulmonary disease. Similar to the patients with emphysema, the patients with chronic lung allograft dysfunction (CLAD) after living-donor lobar lung transplantation (LDLLT) could show emphysematous changes, because in LDLLT, small lobar grafts expand to fit into the recipient's chest cavity due to the size mismatch.