Colorado 'sexual wellness' firm moving to bigger exchange after stock split

An Arapahoe County company that specializes in treating low testosterone in men and diagnosing male infertility is moving its shares to the Nasdaq stock exchange. Aytu BioScience Inc., which engineered a 1-for-20 reverse split in August in an effort to make the move from the over-the-counter bulletin board exchange, said its shares ("AYTU") will begin trading on the Nasdaq exchange on Friday. "To augment our operational progress, we believe that listing on Nasdaq will help the company further diversify…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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Polycystic ovarian syndrome (PCOS) is of frequent occurrence in Saudi females and is often associated with obesity, insulin resistance, hypogonadotropic hypogonadism, and infertility. Since these features are ...
Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
We describe the first case of human male infertility caused by germ cell arrest in a man with AOA2. Our patient has a homozygous mutation in the SETX gene (NC_000009.11:g.135158775dup), which results in a frameshift and premature protein termination (NM_015046.6:c.6422dup, p.[Ser2142Glufs*23]). In accordance with the murine phenotype, testis histology revealed disrupted seminiferous tubules with spermatogonia and primary spermatocytes, but absent spermatids. Collectively, these data support an essential role of senataxin in human spermatogenesis, and provide a compelling case that men with AOA2 should be cou...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
In conclusion, IVM should always be offered as a first-line therapy to infertile women presenting with GROS. The N558H variant discovered in FSHR is novel, but its functional significance, if any, is unresolved and merits further investigation as it may be associated with a recessive FSHR-related disorder.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
CONCLUSIONS: This study demonstrates that 67% of men in infertile couples, who have strict sperm morphology between 5 and 14%, are found to have a potential contributing male factor infertility diagnosis. This raises the possibility that the new lower reference value for sperm morphology may result in missed opportunities for proper infertility assessment. PMID: 30602328 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Authors: Tsang SH, Aycinena ARP, Sharma T Abstract Bardet-Biedl syndrome (BBS) is an autosomal recessive disease with a prevalence of about 1/125,000. The syndrome involves mixed rod-cone dystrophy (which becomes obvious by 6 years of age). About two thirds of patients have postaxial polydactyly, and sometimes syndactyly, brachydactyly, and/or clinodactyly may be present. Hypogonadism and renal involvement occur in about 40%, mental retardation in about 50%, and truncal obesity in about 70%; it is present early, along with insulin resistance, type 2 diabetes, dyslipidemia, and hypertension. Vision becomes ma...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionErectile dysfunction should be considered the most widely researched, published and cited field within andrological practice. This study provides a list of the most influential manuscripts in andrology and serves as a reference of what comprises a ‘highly citable’ paper for both researchers and clinicians.
Source: Basic and Clinical Andrology - Category: Urology & Nephrology Source Type: research
Primary ovarian insufficiency (POI), also known as premature ovarian insufficiency, premature menopause, and hypergonadotropic hypogonadism, is the loss of ovary function before the age of 40 [1]. POI occurs in 1% of the general population, affects 10% of non-ovulating women, and causes infertility and a deficiency in sex steroid production [2]. POI is diagnosed by elevated gonadotropin levels, including levels of serum follicle stimulating hormone (FSH)>40 IU/L after puberty. Recently proposed guidelines for POI diagnosis include a serum FSH  > 30 IU/L after puberty [3].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
igi L Abstract It is universally accepted that lifestyle interventions are the first step towards a good overall, reproductive and sexual health. Cessation of unhealthy habits, such as tobacco, alcohol and drug use, poor nutrition and sedentary behavior, is suggested in order to preserve/improve fertility in humans. However, the possible risks of physical exercise per se or sports on male fertility are less known. Being "fit" does not only improve the sense of well-being, but also has beneficial effects on general health: in fact physical exercise is by all means a low-cost, high-efficacy method for prev...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
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Source: Journal of Neuroendocrinology - Category: Endocrinology Authors: Tags: Original Article Source Type: research
AbstractThe purpose of this study was to investigate the prevalence of androgen receptor gene mutations in idiopathic male infertility in north ‐east China and to analyse the relationship between genotype and phenotype. Cohorts of 400 male patients with idiopathic infertility and 200 fertile controls were recruited. Clinical investigations were carried out by experienced andrologists. Targeted exome sequencing was used to detect androgen receptor gene mutations, and reproductive hormone levels were measured. We found four mutations in 8/400 patients (2%) and no mutations in controls. In addition, two recurrent mutations ...
Source: Andrologia - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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