Colorado 'sexual wellness' firm moving to bigger exchange after stock split

An Arapahoe County company that specializes in treating low testosterone in men and diagnosing male infertility is moving its shares to the Nasdaq stock exchange. Aytu BioScience Inc., which engineered a 1-for-20 reverse split in August in an effort to make the move from the over-the-counter bulletin board exchange, said its shares ("AYTU") will begin trading on the Nasdaq exchange on Friday. "To augment our operational progress, we believe that listing on Nasdaq will help the company further diversify…
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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The established clinical indication for FSH use in male infertility is the treatment of patients with hypogonadotropic hypogonadism for stimulation of spermatogenesis that allows the induction of a clinical pregnancy in the female partner and finally the birth of a healthy child. Several clinical studies with urinary, purified and recombinant FSH preparations in combination with hCG have demonstrated the high treatment efficacy regarding these clinical endpoints. Shortcomings of this hormone therapy are the long duration of treatment, sometimes longer than two years, and the inconvenience of injections every second or thir...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 11 May 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): A. Surbone, L. Vaucher, M.-P. Primi, C. Leyvraz, N. Pitteloud, P. Ballabeni, P. Mathevet, N. VulliemozAbstractClomiphene citrate effect on testosterone level and semen parameters in 18 infertile men with low testosterone level and normal or low gonadotropines level.A. Surbone, L. Vaucher, M.-P. Primi, C. Leyvraz, N. Pitteloud, P. Ballabeni, P. Mathevet, N. VulliemozObjectiveTo determine the effect of a 3-month course of clomiphene citrate (CC) on plasma testosterone (T) level and on semen ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Gonadal impairment represents an important late effect occurring after hematopoietic stem cell transplantation (HSCT), affecting the quality of life of young transplanted patients. The proportion and severity of gonadal late impairment depends on type and cumulative dosage of gonadotoxic chemotherapeutic agents, type of HSCT, age at HSCT, additional use of Total Body Irradiation (TBI) for conditioning or radiotherapy (cranial and pelvic radiotherapy) administered before HSCT [1]. Gonadal complications are recognized as a consequence of myeloablative conditioning regimens, in particular based on TBI or Busulfan (Bu), and in...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
CONCLUSIONS: Sleep is increasingly recognized to be essential for healthy living. Establishing the effect of abnormal sleep, and of improving sleep, on andrological issues of prime interest to men will promote prioritization of sleep, and may thereby improve overall long-term health outcomes. PMID: 31042277 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Abstract Hypogonadotropic hypogonadism (HH) is defined as a dysfunction of hypothalamic-pituitary-gonadal axis, which causes impairments in gametogenesis, pubertal maturation, and/or secretion of the gonadal sex hormones. Human chronic gonadotropin (hCG) stimulates the Leydig cells of the testis to secrete testosterone, which is essential for spermatogenesis. Testosterone replacement therapy is one of the possible options to manage HH treatment. Given the fact that testosterone functions are mediated via androgen receptor (AR), the aim of the present study was to evaluate whether the CAG/GGN triple repeat expansio...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research
Source: Systems Biology in Reproductive Medicine - Category: Sexual Medicine Authors: Source Type: research
Publication date: Available online 24 April 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Giovanni Castellini, Lorenzo Lelli, Emanuele Cassioli, Valdo RiccaAbstractA growing body of evidences demonstrated that sexuality is an important topic in the clinical research of eating disorders (EDs), due to its association with specific psychopathological features, and etiological factors. The present review took into consideration the complex relationship between sexual behaviours, hormonal alterations and EDs psychopathology. Studies pertaining sexual behaviours in EDs were divided into those focusing on sexual dysf...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Authors: Cho CL, Esteves SC, Agarwal A Abstract Varicoceles exert deleterious effect on testicular function. The condition has been associated with male infertility, testicular hypotrophy and pain. These comprises the common indications for varicocele repair currently. Significant improvement in semen parameters and pregnancy outcomes had been suggested by reports decades ago. However, selection of the best candidates remains an issue since not all patients respond positively to treatment. Consensus has been reached in recent decade after the publication of a series of meta-analyses. Significant improvement in preg...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Conclusion: We report the first homozygous nonsense mutation in theGNRHR gene (chr4: g. 68619942G#x3e;A, c.112C#x3e;T, p. Arg38*) that is associated with familial nCHH. Hence, our study displayed a good correlation of the genotype and phenotype of nCHH patients.Horm Res Paediatr 2019;91:1 –8
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
In conclusion, clinicians should be aware of the diagnostic and therapeutic problems in the management of hyperprolactinemia.
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
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