Colorado 'sexual wellness' firm moving to bigger exchange after stock split

An Arapahoe County company that specializes in treating low testosterone in men and diagnosing male infertility is moving its shares to the Nasdaq stock exchange. Aytu BioScience Inc., which engineered a 1-for-20 reverse split in August in an effort to make the move from the over-the-counter bulletin board exchange, said its shares ("AYTU") will begin trading on the Nasdaq exchange on Friday. "To augment our operational progress, we believe that listing on Nasdaq will help the company further diversify…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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Publication date: Available online 15 August 2018Source: SteroidsAuthor(s): Julius Fink, Masahito Matsumoto, Yoshifumi TamuraAbstractSedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of muscle mass, adipose tissue, inflammation and insulin sensitivity and is therefore indirectly regulating several metabolic pathways, while T2D is commonly triggered by insulin resi...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Authors: Barut MU, Çoksüer H, Sak S, Bozkurt M, Ağaçayak E, Hamurcu U, Kurban D, Eserdağ S Abstract BACKGROUND Hypogonadotropic hypogonadism (HH), or secondary hypogonadism, results from reduced secretion of gonadotropins, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH), by the pituitary gland, resulting in lack of production of sex steroids. The aim of this study was to evaluate self-reported sexual function in sexually active women with and without HH using two evaluation methods, the Female Sexual Function Index (FSFI) and the Beck Depression Inventory (BDI). MATERI...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Purpose of review Although platinum-based chemotherapy (CHT) remains the cornerstone of clinical stage I testicular germ cell tumor (GCT) treatment, its long-term toxicity and complications in cancer survivors are unclear. Recent findings Cardiovascular disease and secondary malignancies represent the most life-threatening long-term complications and typically occur 10 years after treatment. Other potential intermediate deleterious effects include pulmonary toxicity, ototoxicity, neurotoxicity, hypogonadism and infertility. The incidence and time to onset vary according to patients’ genetic susceptibility, CHT r...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: TESTICULAR CANCER: Edited by Aditya Bagrodia and Peter Albers Source Type: research
Publication date: Available online 29 July 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Noah J. Levi, Christopher W. Wilson, Graham A.J. Redweik, Nathan W. Gray, Cody W. Grzybowski, Joseph A. Lenkey, Anthony W. Moseman, Alec D. Bertsch, Nhien Dao, Heidi E. WalshAbstractObesity is a risk factor for infertility, but mechanisms underlying this risk are unclear. Fertility is regulated by hypothalamic gonadotropin-releasing hormone, encoded by the Gnrh1 gene. Because obesity promotes endoplasmic reticulum (ER) stress, we sought to determine how tunicamycin-induced ER stress affected Gnrh1 gene expression in the mo...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewOpioids are the cornerstone for pain treatment with significant recent increases in the number of prescriptions. Sexual dysfunction (SD) is a major side effect of opioid therapy. The goal of this review is to examine the current literature on the effects of opioids on male SD (erectile dysfunction [ED], hypogonadism, ejaculatory dysfunction) and infertility.Recent FindingsHigh prevalence of SD exists in men with opioid use as compared to the general population, with an abundance of evidence suggesting an association between opioid use and ED and hypogonadism. There appears to be a role for testoste...
Source: Current Sexual Health Reports - Category: Sexual Medicine Source Type: research
In conclusion, we showed a high incidence of sex chromosome DSD among Egyptian DSD patients with wide karyotype/phenotype diversity. The most frequent sex chromosome DSD detected among patients of the present study was Turner syndrome and variants (52.08%; 25/48) followed by Klinefelter syndrome and variants (43.75%; 21/48). Further long term studies are necessary for accurate detection of frequencies of different types of sex chromosomal anomalies and associated phenotypes. PMID: 30007989 [PubMed - as supplied by publisher]
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - Category: Genetics & Stem Cells Authors: Tags: Sex Dev Source Type: research
In conclusion, we showed a high incidence of sex chromosome DSD among Egyptian DSD patients with wide karyotype/phenotype diversity. The most frequent sex chromosome DSD detected among patients of the present study was Turner syndrome and variants (52.08%; 25/48) followed by Klinefelter syndrome and variants (43.75%; 21/48). Further long term studies are necessary for accurate detection of frequencies of different types of sex chromosomal anomalies and associated phenotypes.Sex Dev
Source: Sexual Development - Category: Biology Source Type: research
Publication date: July 2018Source: Saudi Journal of Biological Sciences, Volume 25, Issue 5Author(s): Ines Jedidi, Mouna Ouchari, Qinan YinAbstractHuman infertility, defined as the inability to conceive after 1 year of unprotected intercourse, is a healthcare problem that has a worldwide impact. Genetic causes of human infertility are manifold. In addition to the chromosomal aneuploidies and rearrangements, single-gene defects can interfere with human fertility. This paper provides a review of the most common autosomal recessive and autosomal dominant single-gene disorders involved in human infertility. The genes reviewe...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: March 2018Source: Arab Journal of Urology, Volume 16, Issue 1Author(s): Scott D. Lundy, Edmund S. SabaneghAbstractDespite being first described two thousand years ago, the varicocele remains a controversial multifaceted disease process with numerous biological consequences including infertility, hypogonadism, and chronic orchidalgia. The underlying mechanisms remain poorly understood and likely include hypoxia, oxidative stress, hyperthermia, anatomical aberrations, and genetics as primary components. Despite a high prevalence amongst asymptomatic fertile men, varicoceles paradoxically also represent the ...
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionsExogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
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