Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse ‐like drinking in high‐alcohol drinker rats

This study supports the neuroinflammation‐chronic ethanol intake hypothesis and suggest that mesenchymal stem cell administration may be considered in the treatment of alcohol use disorders. Neuroinflammation induced by ethanol has been proposed to perpetuate alcohol consumption. Present study shows that the administration of anti‐inflammatory human mesenchymal cells (hMSC) into the cerebrospinal fluid of rats that had consumed ethanol chronically inhibited their alcohol intake by 70% and reduced relapse binge‐like drinking by 80%. Astrocyte neuroinflammation induced in hippocampus by chronic ethanol consumption was fully reversed by hMSC administration. Parallel reversal of oxidative stress (GSSG/GSH) is in line with an oxidative stress–neuroinflammation synergy.
Source: Addiction Biology - Category: Addiction Authors: Tags: Original Article Source Type: research