Nk Cell Recruitment and Exercise: Potential Immunotherapeutic Role of Shear Stress and Endothelial Health

Positive cancer patient outcomes, including increased time to recurrent events, have been associated with increased counts and function of natural killer (NK) cells. NK cell counts and function are elevated following acute exercise, and the generally accepted mechanism of increased recruitment suggests that binding of epinephrine releases NK cells from endothelial tissue via decreases in adhesion molecules following. I propose that blood flow-induced shear stress may also play a role in NK cell recruitment from the endothelium.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research