Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study

Conclusions:
This retrospective multicenter study highlights three important points: the possibility of latent existence and progression of periaortic/periarterial lesions, the efficacy of corticosteroid therapy in preventing new aneurysm formation in patients without luminal dilatation of periaortic/periarterial lesions, and the possibility that a small proportion of patients may actually develop luminal dilatation of periaortic/periarterial lesions in IgG4-related aortitis/periaortitis and periarteritis. To confirm the efficacy and safety of corticosteroid therapy in patients with and without luminal dilatation, and to devise a more useful and safe treatment strategy including administration of other immunosuppressants, a larger-scale prospective study is required.

Source: Arthritis Research and Therapy - July 23, 2014 Category: Rheumatology Authors: Ichiro MizushimaDai InoueMotohisa YamamotoKazunori YamadaTakako SaekiYoshifumi UbaraShoko MatsuiYasufumi MasakiTakashi WadaSatomi KasashimaKenichi HaradaHiroki TakahashiKenji NotoharaYasuni NakanumaHisanori UmeharaMasakazu YamagishiMitsuhiro Kawano Source Type: research