Variable course of Unverricht-Lundborg disease: Early prognostic factors

Conclusions:
A younger age at onset, early severe myoclonus, and seizure persistence are predictors of a more severe outcome. All of these factors may be genetically determined, but the greater hyperexcitability underlying more severe seizures and myoclonus at onset may also play a role by increasing cell damage due to reduced cystatin B activity.

Source: Neurology - October 16, 2017 Category: Neurology Authors: Canafoglia, L., Ferlazzo, E., Michelucci, R., Striano, P., Magaudda, A., Gambardella, A., Pasini, E., Belcastro, V., Riguzzi, P., Fanella, M., Granata, T., Beccaria, F., Trentini, C., Bianchi, A., Aguglia, U., Panzica, F., Franceschetti, S. Tags: Myoclonus; see Movement Disorders/myoclonus, Natural history studies (prognosis), EEG, Generalized seizures ARTICLE Source Type: research