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Hereditary persistence of hemoglobin F is protective against red cell sickling. A case report and brief review

We describe a case of SCD, in which a patient with high HbF level presented at a very late age (27 years old). We presume the patient’s inherently elevated HbF levels were able to compensate for the hypoxic episodes associated with SCD. The onset of symptoms was delayed as a result of elevated HbF levels.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research

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Authors: Galluzzo M, D'Adamio S, Bianchi L, Talamonti M Abstract Psoriasis tends to improve for approximately half of patients during pregnancy, but an equal number of patients report no change or worsening during this period, when lots of medications, like biologics, are not indicated. The aim of our study was to review data of patient that had been pregnant during ustekinumab treatment, analyzing data of our data set between September 2010 and February 2018. We found data of three patients that had been pregnant during ustekinumab treatment. All three patients successfully completed the pregnancy without complica...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Abstract Bladder Cancer (BC) presents one of the highest recurrence rates amongst solid tumours and constitutes the second deadliest disease of the genitourinary track. Non-invasive identification of patients facing disease recurrence and/or progression remains one of the most critical and challenging aspects in disease management. To contribute to this goal, we demonstrate the potential of glycan-affinity glycoproteomics nanoplatforms for urinary biomarkers discovery in bladder cancer. Briefly, magnetic nanoprobes (MNP) coated with three broad-spectrum lectins, namely Concanavalin A (ConA; MNP@ConA), Wheat Germ A...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Corrigendum to "Visual Acuity Changes during Pregnancy and Postpartum: A Cross-Sectional Study in Iran". J Pregnancy. 2018;2018:5280697 Authors: Mehdizadehkashi K, Chaichian S, Mehdizadehkashi A, Jafarzadepour E, Tamannaie Z, Moazzami B, Pishgahroudsari M Abstract [This corrects the article DOI: 10.1155/2014/675792.]. PMID: 29675277 [PubMed - in process]
Source: Journal of Pregnancy - Category: OBGYN Tags: J Pregnancy Source Type: research
Current and emerging two-drug approaches for HIV-1 therapy in ART-naïve and ART-experienced, virologically suppressed patients. Expert Opin Pharmacother. 2018 Apr 20;:1-26 Authors: Rossetti B, Montagnani F, De Luca A Abstract INTRODUCTION: Current guidelines recommend a 2-drug antiretroviral regimen as an alternative to triple antiretroviral therapy (ART) in selected patients to reduce long-term toxicity and costs. Areas covered: This review is intended to provide insight into the efficacy, safety and tolerability of 2-drug versus 3-drug ART in naïve and in treatment-experienced virologically...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
CONCLUSION: UAL and SAL lipoaspirates are suitable for obtaining functional ASCs and are comparable to minimally manipulated cells from abdominoplasty resections. PMID: 29672782 [PubMed - in process]
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
Inflammatory Human Umbilical Cord-Derived Mesenchymal Stem Cells Promote Stem Cell-Like Characteristics of Cancer Cells in an IL-1β-Dependent Manner. Biomed Res Int. 2018;2018:7096707 Authors: Luo X, Huang S, He N, Liu C, Chen Y, Liu Y, Mi X, Li N, Sun P, Li Z, Xiang R, Su W Abstract To ensure the safety of clinical applications of MSCs, thorough understanding of their impacts on tumor initiation and progression is essential. Here, to further explore the complex dialog between MSCs and tumor cells, umbilical cord-derived mesenchymal stem cells (UC-MSCs) were employed to be cocultured with either ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In this study, we intended to find the effect of T-614 on the osteogenesis process. We detected osteogenesis markers and transcription factors associated with osteoblastic lineage and bone formation in the culture of mesenchymal stem cells which differentiate osteoblast. The contents and activity of alkaline phosphatase, levels of collagen type I and bone gla protein, and calcium nodule formation were increased significantly after T-614 treated. Meanwhile, the mRNAs expressions of Osterix and Dlx5 were also found to be increased significantly by real-time PCR. The changes of levels of phosphorylation of p38 and NF-κB...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
A red cell distribution width (RDW) blood test can help detect the presence of anemia, along with what could be causing it. The test identifies the size difference between the biggest and smallest red blood cells in a sample. In this article, we look at what to expect when having this test, and when it might be used.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Blood / Hematology Source Type: news
CONCLUSION: Our observations highlight the difficulty to diagnose this complication with often non-specific clinical presentation and possible delayed occurrence after to transplantation, but also the therapeutic challenges, defibrotide being the only agent currently efficient. Physiopathology and potential responsibility of bendamustine in the sinusoidal obstruction syndrome occurrence will be discussed. PMID: 29673920 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Happy Saturday, Psych Central readers! This week’s Psychology Around the Net takes a look at the new 3-D mini-brains researchers are using to better study the connection between severe mental illnesses, how we can make insecurity work for us (yes, you read that correctly), studies that take a closer look at mental health challenges LGBTQ youth face, and more. 3-D ‘Mini-Brains’ Shed Light On Mental Illness: Some mental illnesses such as severe depression, bipolar disorder, and schizophrenia share a common genetic link, and now researchers have used human stem cells to create a 3-D model of the brain to be...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Bullying Children and Teens Psychiatry Psychology Around the Net Research Sexuality 3-D brain Bisexual bright side Gay Hattie Gladwell human stem cells insecure Lesbian LGBTQ Mental Health Care Mental I Source Type: blogs
More News: African Health | Anemia | Aplastic Anemia | Cancer & Oncology | Genetics | Hematology | Hepatocellular Carcinoma | India Health | Liver Cancer | Myelodysplastic Syndrome | Myeloproliferative Disorders | Pregnancy | Sickle Cell Anemia | Stem Cell Therapy | Stem Cells