Hereditary persistence of hemoglobin F is protective against red cell sickling. A case report and brief review

We describe a case of SCD, in which a patient with high HbF level presented at a very late age (27 years old). We presume the patient’s inherently elevated HbF levels were able to compensate for the hypoxic episodes associated with SCD. The onset of symptoms was delayed as a result of elevated HbF levels.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research

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2019 has become the year when antiabortion politicians make clear that their ultimate agenda is banning abortion outright, at any stage in pregnancy and for any reason.
Source: The Guttmacher Institute - Category: International Medicine & Public Health Authors: Source Type: news
This study compares the effects of rFSH only, rLH + rFSH, and HMG + rFSH administration on in vitro fertilization (IVF) outcomes for patients in three different yearly follow-up cycles. Material and methods: This retrospective, single-center cohort study was conducted from January 2001 to June 2016 at Istanbul Memorial Hospital, Artificial Reproductive Technology Center. From a total of 27,024 IVF cycles in women aged 18 to 45 years (17,536 rFSH only; 2147 rLH + rFSH; 7341 HMG + rFSH), the results of 2,147 cycles receiving a treatment of rLH + rFSH over the 3-year evaluation and 2,081 total cycles in which rLH + rFSH w...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Conclusions: The IVF singleton pregnancies have an increased risk of adverse perinatal outcome, among which prematurity remains the greatest problem. Therefore, they should be managed as high risk not only due to psychological reasons. PMID: 31110532 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
A lot of IVF clinics take pride in the large number of cycles which they do . Their focus is on their turnover, because they are profit making corporates, who need to maximise their ROI for their investors.While is great for the management because this maximizes their revenue, it may not be good for each individual patient they treat. They use an assembly line approach, where every patient is treated as a widget, and the focus is on maximising throughput by using a "one-size-fits-all" approach.Our focus as a boutique clinic is very different ! We make sure that we spend a lot of time and energy on each individual...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Publication date: Available online 22 May 2019Source: The Saudi Dental JournalAuthor(s): C. Rahila, M.B. Aswath Narayanan, S.G. Ramesh Kumar, A. Leena Selvamary, A. Sujatha, J. John KirubaharanAbstractIntroductionDental fluorosis is a foremost public health problem in many countries, including India. Very few studies investigated gene polymorphism and risk of dental fluorosis. Genetic polymorphisms in Collagen Type I, alpha 2 (COL1A2) gene, found to be linked with bone pathogenesis, may affect the tooth formation resulting in the vulnerability to dental fluorosis.AimTo assess the association between COL1A2 (PvuII) gene pol...
Source: The Saudi Dental Journal - Category: Dentistry Source Type: research
CONCLUSIONS: NEK2 plays a significant role in cell cycle progression in the inter- and M-phases. NEK2 enhances HCC metastasis and is correlated with recurrence and thus can potentially serve a promising high-risk biomarker for HCC. PMID: 31104800 [PubMed - in process]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
CONCLUSIONS: Treatment with LDV/SOF with/without RBV for 12-24 weeks was very well tolerated and resulted in high SVR 12 rates (96%) in HCV GT1 relapsers to SMV + SOF treatment. PMID: 31104796 [PubMed - in process]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Authors: Shiha GE, El-Etreby S, Bahgat M, Hamed M, Sherbini ME, Ghoneem EA, Zalata K, Soliman RE, ElBasiouny MA, Mikhail NN Abstract INTRODUCTION AND AIM: Transient elastography is gaining popularity as a non-invasive method for predicting liver fibrosis, but inter observer agreement and factors influencing reproducibility have not been adequately assessed. MATERIAL AND METHODS: This cross-sectional study was conducted at Specialized Medical Hospital and the Egyptian Liver Foundation, Mansoura, Egypt. The inclusion criteria were: age older than 18 years and chronic infection by hepatitis C. The exclusion criter...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patients with the NaV1.7/I848T mutation into sensory nociceptors. Action potentials in these IEM nociceptors displayed a decreased firing threshold, an enhanced upstroke, and afterhyperpolarization, all of which may explain the increased pain experienced by patients. Subsequently, we investigated the voltage dependence of the tetrodotoxin-...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
We describe a case of SCD, in which a patient with high HbF level presented at a very late age (27 years old). We presume the patient’s inherently elevated HbF levels were able to compensate for the hypoxic episodes associated with SCD. The onset of symptoms was delayed as a result of elevated HbF levels.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
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