Ethiopia:Ministry Eyes At Strengthening Onchocerciasis Elimination Efforts

[Ethiopian Herald] Ministry of Health and development partners disclosed that the program to eliminate Onchocerciasis - disease caused by parasitic worm - is progressing in most affected areas of the country.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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by Alexandra Grote, Yichao Li, Canhui Liu, Denis Voronin, Adam Geber, Sara Lustigman, Thomas R. Unnasch, Lonnie Welch, Elodie Ghedin Filarial nematodes can cause debilitating diseases in humans. They have complicated life cycles involving an insect vector and mammalian hosts, and they go through a number of developmental molts. While whole genome sequences of parasitic worms are now available, very little is known about transcr iption factor (TF) binding sites and their cognate transcription factors that play a role in regulating development. To address this gap, we developed a novel motif prediction pipeline, Emotif Alph...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
We present crystal structures of the butenolide receptor AvaR1 in is olation, and in complex with avenolide, as well as AvaR1 bound to an oligonucleotide derived from its operator. Biochemical studies guided by the co-crystal structures enable identification of 90 new actinobacteria that may be regulated by butenolides, two of which are experimentally verified. These studies provide a foundation for understanding regulation of microbial secondary metabolite production, which may be exploited for the discovery and production of novel medicines.
Source: eLife - Category: Biomedical Science Tags: Biochemistry and Chemical Biology Source Type: research
(Washington University School of Medicine) Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health (NIH) totaling more than $5 million to study two types of parasitic worm infection that cause devastating illness in millions of people worldwide. One project will focus on onchocerciasis, commonly known as river blindness. The second project will target fascioliasis, commonly found in cattle-farming operations.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Little information is available on the effect of ivermectin on the third- and fourth-stage larvae of Onchocerca volvulus. To assess a possible prophylactic effect of ivermectin on this parasite, we compared the e...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Abstract Onchocerciasis is a neglected tropical disease caused by a nematode parasite, Onchocerca volvulus, and transmitted by bites of Simulium blackflies which breed near fast-flowing rivers. In humans thousands of microfilariae (immature worms) migrate to the skin and eyes where they cause pathology. Historically, much research was devoted to the serious effect of blindness, from which the disease earns its alternative name of "river blindness". Mapping the burden of onchocercal skin disease (OSD) was expedited by the development of a clinical classification and grading system which facilitated compar...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Zoonotic onchocerciasis is a vector-borne disease, which involves many animal species, including large ungulates, boars, dogs, and sporadically, humans. So far, 39 cases of zoonotic onchocerciasis have been re...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Short report Source Type: research
Answer toParasite Case of the Week 580:Loa loamicrofilariae. As noted by several readers, the nuclei go to the tip of the tail, the microfilariae are relatively large, and there is faint evidence of a sheath, all of which are characteristic features for this species. As I teach my students, the nuclei " flow-a flow-a " (to the tip) in Loa loa. Another memory trick from William Sears is that the nuclei go " lower and lower " in Loa loa. Take your pick for your favorite! Remember that the sheath will not always be seen. Size is a more definitive feature in differentiating Mansonella spp. from th...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Abstract Plateau and Nasarawa states in central Nigeria were endemic for onchocerciasis. The rural populations of these two states received annual ivermectin mass drug administration (MDA) for a period of 8-26 years (1992-2017). Ivermectin combined with albendazole was given for 8-13 of these years for lymphatic filariasis (LF); the LF MDA program successfully concluded in 2012, but ivermectin MDA continued in areas known to have a baseline meso-/hyperendemic onchocerciasis. In 2017, serological and entomological assessments were undertaken to determine if MDA for onchocerciasis could be stopped in accordance with...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
The genus Onchocerca Diesing, 1841 includes species of medical importance, such as O. volvulus (Leuckart, 1893), which causes river blindness in the tropics. Recently, zoonotic onchocercosis has been reported in ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Conclusions/SignificanceThese provide support to the conclusion that onchocerciasis has been eliminated from Mexico.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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