Electroacupuncture alleviates chemotherapy ‐induced pain through inhibiting phosphorylation of spinal CaMKII in rats

ConclusionsElectroacupuncture activates 5‐HT 1A receptors in the spinal cord and inhibits p‐CaMKII to alleviate both allodynia and hyperalgesia. The data support acupuncture/EA as a complementary therapy for CIP. SignificanceElectroacupuncture (EA) activates spinal 5‐HT1A receptors to inhibit p‐CaMKII to alleviate paclitaxel‐induced pain. Acupuncture/EA may be used as a complementary therapy for CIP.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research

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You're reading Here’s What Yoga Can Do For You, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. It`s International Yoga Day people. I was thinking about doing yoga over the past three months, and because of my analytical nature, I decided to do some quick research on its benefits. And since we're celebrating International Yoga Day this month, I decided to show you the six key benefits practicing yoga will give you. Here they are: Yoga will make you calmer Yoga is so great at regulating stress that researchers ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured happiness health and fitness anxiety benefits of yoga international yoga day mental health pickthebrain Source Type: blogs
Medtronic (NYSE:MDT) said yesterday it won expanded FDA 510(k) clearance for its Kyphon HV-R bone cement designed for the fixation of pathological fractures of the sacral vertebral body. The Fridley, Minn.-based company’s Kyphon HV-R bone cement is now indicated for treating pathological fractures of the vertebral body due to osteoporosis, cancer or benign lesions using a cementoplasty procedure. The cement is also indicated for the fixation of pathological fractures of the sacral vertebral body or ala using sacral vertebroplasty or sacroplasty, the company said. “Patients who experience sacral insuff...
Source: Mass Device - Category: Medical Devices Authors: Tags: 510(k) Orthopedics Regulatory/Compliance Spinal Medtronic Source Type: news
This study evaluated its antihypersensitivity activity in the rat models of neuropathic and cancer pains and explored its underlying mechanisms. Subcutaneous injection of cumulative doses of lappaconitine produced dose-dependent mechanical antiallodynia and thermal antihyperalgesia in spina l nerve ligation-induced neuropathic rats. The cumulative dose–response analysis exhibited theirEmax values of 53.3 and 58.3% MPE, and ED50 values of 1.1 and 1.6  mg/kg. Single intrathecal lappaconitine dose in neuropathy also dose- and time-dependently blocked mechanical allodynia, with anEmax of 66.1% MPE and an ED50 of 0.8...
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Lung cancer is the leading cause of cancer-related death worldwide [1], and bone metastases occur in 20-30 % of patients with lung cancer [2]. Bone metastases result in several unfavorable skeletal-related events (SREs), including bone pain, pathological fractures, spinal cord compression, hypercalcemia, and the need for bone radiation. SREs have a negative effect on the quality of life (QOL) of cancer patients [3]. Zoledronate (ZOL), a nitrogen-containing bisphosphonate (N-BP), has been shown to reduce the incidence of SREs in cancer patients with bone metastases, including lung cancer [4].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Abstract Since Cav3.2 T-type Ca2+ channels (T-channels) expressed in the primary afferents and CNS contribute to intractable pain, we explored T-channel-blocking components in distinct herbal extracts using a whole-cell patch-clamp technique in HEK293 cells stably expressing Cav3.2 or Cav3.1, and purified and identified sophoraflavanone G (SG) as an active compound from SOPHORAE RADIX (SR). Interestingly, hop-derived SG analogues, (2S)-6-prenylnaringenin (6-PNG) and (2S)-8-PNG, but not naringenin, also blocked T-channels; IC50 (μM) of SG, (2S)-6-PNG and (2S)-8-PNG was 0.68-0.75 for Cav3.2 and 0.99-1.41 for ...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
BACK pain - particularly pain in the lower back - is a common problem that affects most people at some point in their life. Lower back pain could be a sign of cancer, patients have been warned. These are the symptoms of a spinal tumour to look out for - is your back pain a sign of something serious?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion The IM protocol is used in WDP since 2007. The participative dimension appears underused. Few theoretical frameworks were used. Implications are to better consider the stakeholders involvement, and mobilize theoretical frameworks with greater attempts to intervene on the work environment.
Source: Journal of Occupational Rehabilitation - Category: Rehabilitation Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, the data indicate that NPY is involved in the spinal nociceptive signaling of cancer-induced bone pain and could be a new therapeutic target for patients with this condition.
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 2 June 2018 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Author(s): J. Orcajo-Rincon, A.P. Caresia-Aróztegui, M. del Puig Cózar-Santiago, J.R. García-Garzón, M. de Arcocha-Torres, R.C. Delgado-Bolton, M.J. García-Velloso, S. Alvarez-Ruiz, A.M. García-Vicente Bone metastatic disease is the main cause of morbidity/mortality in patients with prostate cancer, presenting frequently as bone pain, pathological fractures or spinal cord compression, which requires early and timely therapy. Although, for the momen...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
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