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Electroacupuncture alleviates chemotherapy ‐induced pain through inhibiting phosphorylation of spinal CaMKII in rats

ConclusionsElectroacupuncture activates 5‐HT 1A receptors in the spinal cord and inhibits p‐CaMKII to alleviate both allodynia and hyperalgesia. The data support acupuncture/EA as a complementary therapy for CIP. SignificanceElectroacupuncture (EA) activates spinal 5‐HT1A receptors to inhibit p‐CaMKII to alleviate paclitaxel‐induced pain. Acupuncture/EA may be used as a complementary therapy for CIP.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research

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This study shows that andrographolide inhibits the development of osteoclasts ( = the cells that chew away at our bones, which is fine in a healthy situation, not fine in cancer where everything goes nutso), while increasing the presence of osteoblasts (bone builders). The researchers say that the current therapies used to treat osteolytic diseases have many unwanted side effects. And they’re not just referring to bisphosphonates (which can cause osteonecrosis of the jaw) but also to new treatments such as the monoclonal antibody denosumab, Denosumab can cause low calcium levels, weakness, constipation, bac...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll Source Type: blogs
New research, which was presented at the American Association for the Advancement of Science’s annual conference, has found that moderate drinking is linked to a longer life. Drinking about two glasses of wine or beer a day was linked to an 18% drop in a person’s risk of early death—an even stronger effect than the life-preserving practice of exercise, according to the researchers. The results came from the 90+ Study, a research project out of the University of California Irvine’s Institute for Memory Impairments and Neurological Disorders that examines the habits of people who live to at least 90. ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime onetime Source Type: news
I have lots of aches and pain. This is a proven fact. You can ask any of my doctors. And I am also a klutz. And I have the battle scars to prove it.Last week, I tripped over my father's wheelchair in the waiting room of the chemotherapy department. How embarrassing. In front of maybe 40 people waiting for their appointments. They all noticed.This is what happened. We arrived at the hospital and my father grabbed a wheelchair. He has a bad leg so he pushes a wheelchair around instead of using a cane or walker. It's easier for him. He checked in for his appointment and we sat down to wait for him to be called. He parked the ...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: brainless cancer bonds falls klutziness more pain Source Type: blogs
CANCER symptoms vary depending on which part of the body is affected by the tumour. Back pain and weight loss could be a sign of the bladder disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
If you’ve been following the Wheat Belly discussions, you already know that efforts to cultivate healthy bowel flora in the wake of wheat/grain elimination is a key factor in regaining health. While I’ve emphasized the importance of a high-potency (e.g., 50 billion or more CFUs per day), multi-species probiotic supplement and prebiotic fibers, I’ve not focused on the importance of fermented foods. This issue comes to light in particular with our experience in battling small intestinal bacterial overgrowth, or SIBO. Dysbiosis, or disrupted composition of bowel flora in the colon, is exceptionally common, e...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle bowel flora fermented foods grain-free Inflammation kefir kimchi kombucha probiotic sibo small intestinal bacterial overgrowth yogurt Source Type: blogs
ConclusionsMultimodal modular exercise in prostate cancer patients with bone metastases led to self-reported improvements in physical function and objectively measured lower body muscle strength with no skeletal complications or increased bone pain.Trial Registration: ACTRN12611001158954. Purpose The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting because of concerns of fragility fracture. We examined the efficacy and safety of a modular multimodal exercise program in prostate cancer pa...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Clinical Sciences Source Type: research
Development of chronic pain associated with chemotherapy-induced peripheral neuropathy (CIPN) compromises the effectiveness of chemotherapies to treat cancers and greatly impacts thousands of lives. The causative mechanisms remain poorly understood. However, emerging evidence implicates unchecked neuroinflammation as a determinant factor in its development. We now demonstrate that the dysregulation of adenosine metabolism and loss of its signaling govern the extent of neuroinflammation in oxaliplatin-treated rodents.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
In this study, we examined the changes of spinal ROS and ROS-induced oxidative DNA damages, and also evaluated the analgesic effect of N-tert-Butyl-aphenylnitrone (PBN), a non-specific ROS scavenger, in a rat model of CIBP.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Abraham Lincoln, who would have celebrated his 209th birthday on Feb. 12, left behind an impressive legacy during his time in office — but many Americans still associate the 16th president, first and foremost, with his towering height. Standing 6’4″, Lincoln is, to this day, the tallest president ever, edging out Lyndon Johnson by a full inch. Height wasn’t Lincoln’s only distinguishing physical characteristic. While he was in office, a journalist described the president’s “long pendulous arms” and “hands of extraordinary dimensions…far exceeded in proportion by ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Abraham Lincoln healthytime onetime Source Type: news
CANCER symptoms vary depending on where the tumour is in the body. But, you should never ignore back pain, because it could be a sign of pancreatic cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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