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Electroacupuncture alleviates chemotherapy ‐induced pain through inhibiting phosphorylation of spinal CaMKII in rats

ConclusionsElectroacupuncture activates 5‐HT 1A receptors in the spinal cord and inhibits p‐CaMKII to alleviate both allodynia and hyperalgesia. The data support acupuncture/EA as a complementary therapy for CIP. SignificanceElectroacupuncture (EA) activates spinal 5‐HT1A receptors to inhibit p‐CaMKII to alleviate paclitaxel‐induced pain. Acupuncture/EA may be used as a complementary therapy for CIP.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research

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This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Opinion statementSpinal metastases are the most commonly encountered tumour of the spine, occurring in up to 40% of patients with cancer. Each year, approximately 5% of cancer patients will develop spinal metastases. This number is expected to increase as the life expectancy of cancer patients increases. Patients with spinal metastases experience severe and frequently debilitating pain, which often decreases their remaining quality of life. With a median survival of less than 1  year, the goals of treatment in spinal metastases are reducing pain, improving or maintaining level of function and providing mechanical stab...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
It was in January 2015 that mother and school teacher Natalie Dunne began having back pain after eating or drinking milk products. Little did she know that the cause was pancreatic cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
As The Author of Minding Our Elders: Caregivers Share Their Personal Stories, I'm honored to be chosen to be part AlzAuthors. This post is courtesy of AlzAuthors. Read through for some incredible deals on ebooks written by authors who've been where you are. MOE is among the books on sale. All are $2.99 or less. November is National Caregiver Appreciation Month, a time to recognize the long hours, sacrifice, and love all caregivers bring to the task of caring for a loved one with dementia or any long-term illness. In honor of their efforts, AlzAuthors is hosting an eBook sale and giveaway! This is a terrific way f...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
The widespread U.S. opioid &overdose crisis is an ever-increasing tragic concern for everyone: writhing victims, family members being fain to see their relatives suffer or die, doctors prescribing opioid pain-killers what they thought before as safe, and regulators imposed to handle a tough situation. Addiction. It’s painful to even read about the skyrocketing numbers of people suffering, thus we decided to map how digital health could help tackle the opioid crisis. Why is it so difficult to deal with the opioid crisis? Once you become addicted, it sticks with you for a long time, if not for life, just as a ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Bioethics Mobile Health Virtual Reality in Medicine AI artificial intelligence data data analytics drugs future gc3 Innovation opioid opioid crisis pharma technology wearables Source Type: blogs
AbstractBreast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with significantly increased osteoclast and osteoblast activity, which has provided a rational target for controlling tumor progression, with little or no emphasis on tumor eradication. Indeed, the clinical course of metastatic breast cancer is relatively long, with patients likely to experience sequential skeletal-related events (SREs), often over lengthy periods of time, ev...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Abstract Vertebral pathological fracture and metastatic epidural spinal cord compression (MESCC) due to metastatic cancer inevitably cause pain, neurological deficit, impaired function, and decreased quality of life and are indications for surgery. In such cases, earlier surgical intervention has the potential to prevent permanent neurological deficit and disability and to maintain function and quality of life. Therefore, the aim of this study was to identify and evaluate risk factors for pathological fracture and MESCC in patients with spinal metastases. Retrospective assessment of clinical and radiological param...
Source: Orthopedics - Category: Orthopaedics Authors: Tags: Orthopedics Source Type: research
Conclusions Patients expect outpatient imaging results within 1 to 3 days and will call providers by 1 to 5 days. Waiting for test results commonly induces anxiety.
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
BACK PAIN around the middle of your back could be a symptom of pancreatic cancer, along with abdominal pain and indigestion.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
7 a.m. began as it always did; the overnight doc was threatening to quit while rubbing her bloodshot eyes and smearing mascara beneath them. Between heavy sighs, she listed the patients transferring into my care ending with Mr. Mandel. “He’s eighty-something,” she explained, “hospice care. Cancer with metastases. Came in from home because family ran out of morphine and he was in a lot of pain. Anyway, he’s actively dying now, so they don’t really want to put him back in the car and drive him home.” With that, she shoved a handful of dry cereal in her mouth and shuffled out. I hung ...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Hospital-Based Medicine Oncology/Hematology Source Type: blogs
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