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Immunotherapy Side Effects: New Global Guidelines for Nurses Immunotherapy Side Effects: New Global Guidelines for Nurses

Immunotherapy has revolutionized cancer therapy, but these drugs have unique and sometimes life-threatening adverse events, as outlined in the new guidelines.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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In the past decade, the resurgence of immunotherapy has changed the landscape of cancer therapy. Checkpoint inhibitors targeting cytotoxic T-lymphocyte antigen-4, programmed death-1 on lymphocytes, and programmed death ligand-1 on tumors cells are currently utilized in the management of several cancers. These agents are double-edged sword with the positive effect being robust antitumor response but on the other side they can throttle up the normal immunologic homeostasis in a negative way, leading to adverse autoimmune toxicities. These adverse toxicities are frequent if patients have active autoimmune disorders. Here, we ...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Case Reports Source Type: research
Conclusions: SSA is highly effective at preserving samples for molecular testing from EBUS-FNA. Therefore a single minimally invasive procedure offers access to novel immunotherapy, enhancing lung cancer care. With increasing emphasis on immunotherapy its value is likely to increase.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
In this study, we integrated atomic force microscopy (AFM) and molecular approaches to determine whether increased stiffness of aortic VSMCs in hypertensive rats is ROCK-dependent, and whether the anti-hypertensive effect of ROCK inhibitors contributes to the reduction of aortic stiffness via changing VSMC mechanical properties. Despite a widely held belief that aortic stiffening is associated with changes in extracellular matrix proteins and endothelial dysfunction, our recent studies demonstrated that intrinsic stiffening of aortic VSMCs, independent of VSMC proliferation and migration, is an important contributo...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - Category: Internal Medicine Authors: Tags: Invited Review Source Type: research
Abstract The enthusiasm about successful novel therapeutic strategies in cancer is often quickly dampened by the development of drug resistance. This is true for targeted therapies using tyrosine kinase inhibitors for EGFR or BRAF mutant cancers, but is also an increasingly recognized problem for immunotherapies. One of the major obstacles of successful cancer therapy is tumor heterogeneity of genotypic and phenotypic features. Historically, drivers for drug resistance have been suspected and found on the genetic level, with mutations either being pre-existing in a subset of cancer cells or emerging de novo to med...
Source: Journal of Cell Communication and Signaling - Category: Molecular Biology Authors: Tags: J Cell Commun Signal Source Type: research
The National Institutes of Health has joined 11 biopharmaceutical companies in establishing a Partnership for Accelerating Cancer Therapies (PACT), a 5-year, $215 million research collaboration to identify biomarkers that will help personalize treatments that harness the immune system to attack cancer.
Source: JAMA - Category: General Medicine Source Type: research
Authors: Tagliabue L, Capozza A, Maioli C, Luciani A, Ierardi AM, Carrafiello G Abstract Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
Conclusion: Based on the biological effects of oral candidate probiotics candidate bacterium L. plantarum on functional expression of PTEN and MAPK pathways, this microorganism seems to play a key role in controlling undesired cancer development in the oral system. Taken all, L. plantarum is proposed as a potential candidate for probiotics cancer therapy. PMID: 29159146 [PubMed]
Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research
The clinical promise of cancer immunotherapy relies on the premise that the immune system can recognize and eliminate tumor cells identified as non-self. The success of cancer immunotherapy is limited by tumor immune evasion, preventing long-lasting tumor control. Recent evidence suggests that certain anticancer therapies can alter the biology of the surviving cell population to restore their sensitivity to T-cell-mediated lysis and help treat patients.Researchers at theNCI Laboratory of Tumor Immunology and Biology developed a method of reducing cancer cell growth by treating cancer cells with a combination of a histone d...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
This article is protected by copyright. All rights reserved. PMID: 29150846 [PubMed - as supplied by publisher]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
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