Solitary plexiform neurofibroma determining pyloric obstruction: a case report

Solitary gastric plexiform neurofibroma (PN) is a very rare tumor that originates from the peripheral nerves. PN is a rare cause of pyloric obstruction. A 58 year-old man, reported epigastric discomfort, nausea, and vomiting for two months. Upper digestive endoscopy showed a moderate/accentuated pyloric stenosis. Computed tomography (CT) and echoendoscopy revealed a pyloric nodule. The patient underwent to distal gastrectomy. Macroscopically, a gray nodule measuring 1.1 × 1.0 × 1.0 cm was identified. Using microscopy, a benign tumor composed of enlarged tortuous nerve fascicles showing a neurofibromatous proliferation with mild atypia and myxoid matrix was found. The lesion showed positive immunoexpression for S100, Leu7, and epithelial membrane antigen (EMA), and was negative for CD117, DOG-1, desmin, and smooth muscle actin. The diagnosis of PN was then determined.Neurofibroma plexiforme (NP) gástrico solitário é um tumor muito raro originado a partir dos nervos periféricos. É uma causa rara de obstrução pilórica. Paciente masculino, 58 anos, relatava desconforto epigástrico, náuseas e vômitos durante dois meses. A endoscopia digestiva superior mostrou estenose moderada/acentuada do piloro. Tomografia computadorizada (TC)/ ecoendoscopia revelaram nódulo no piloro. O paciente foi submetido a gastrectomia distal. À macroscopia, identificou-se nódulo cinzento medindo 1....
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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ConclusionSymptoms of pyloric obstruction as a manifestation of isolated gastric Crohn ’s disease are extremely unusual in clinical practice, awareness of which would facilitate early appropriate investigations and treatment.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
The real pathogenesis of Pyloric Stenosis of Infancy (PS) is becoming clearer: [1] Inherited hyperacidity starts the process, [2] Acid stimulated sphincter contraction follows, [3-5] Repeated contraction by attracting growth factors locally causes sphincter hypertrophy, especially marked in the trophic ambience of the temporarily hypergastrinaemic baby [6] [7]. It can be no coincidence that peak acidity occurs in all normal babies at around 3 –4 weeks of age, the classical time that symptoms develop [8].
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Tags: Correspondence Source Type: research
Conditions:   Infantile Hypertrophic Pyloric Stenosis;   Pyloromyotomy Intervention:   Procedure: G-POEM Sponsor:   Shanghai Zhongshan Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
k J Abstract Selective internal radiation therapy (SIRT) is a therapeutic option for primary and metastatic liver tumors. Microspheres containing Yttrium 90, a beta-emitting radionuclide, are administered into the hepatic artery allowing selective internal radiation of a liver tumor. SIRT-related complications may appear due to migration of the radiation microspheres to organs distant from the tumor site. In order to prevent these complications, unintended non target embolization of Yttrium microspheres has to be avoided. However, data from external-beam radiation therapy (EBRT) suggests that the stomach/small bow...
Source: Zeitschrift fur Gastroenterologie - Category: Gastroenterology Authors: Tags: Z Gastroenterol Source Type: research
Abstract An 11-year-old, neutered female, Labrador retriever dog was presented with a history of intractable vomiting, regurgitation, and coughing. Computed tomography (CT) imaging identified marked hypertrophy of the distal esophagus with a suspicion of distal esophageal achalasia, based on the observation of a "bird beak" appearance. This was later confirmed on a fluoroscopic swallow study. Marked hypertrophy of the gastric pylorus was also identified on CT imaging, and polypoid gastric mucosal hyperplasia was diagnosed based on the gross endoscopic appearance combined with gastric histopathology. Seco...
Source: The Canadian Veterinary Journal - Category: Veterinary Research Authors: Tags: Can Vet J Source Type: research
Endoscopy DOI: 10.1055/a-1022-4274 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text
Source: Endoscopy - Category: Gastroenterology Authors: Tags: E-Videos Source Type: research
Publication date: Available online 22 October 2019Source: Surgery (Oxford)Author(s): Andrew R Ross, Paul R.V. JohnsonAbstractInfantile hypertrophic pyloric stenosis (IHPS) is the most common cause of gastric outlet obstruction in infants and is one of the most common conditions requiring surgery in the newborn. It arises from marked hypertrophy of the pyloric muscle (primarily circular layer), resulting in partial or complete luminal occlusion. Classically these infants have persistent non-bilious vomiting, are dehydrated with weight loss, and have a hypokalaemic, hypochloraemic metabolic alkalosis. Treatment requires init...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
​The back story of pyloric stenosis is fascinating. It is a relatively minor surgical condition today, but the disease had a mortality of 100 percent before 1904, when only five operative cases were known to have been performed in the United States. The dying process was slow and painful, and parents watched their infants slowly starve to death.The pyloromyotomy procedure currently used to treat pyloric stenosis was introduced by Conrad Ramstedt, MD, in 1911 at the Children's Hospital of Munster, and is still called the Ramstedt procedure. Before surgical management was introduced for this gastric outlet obstruction, mul...
Source: M2E Too! Mellick's Multimedia EduBlog - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
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