The Kidney and CVOTs

Abstract Chronic kidney disease (CKD) affects a substantial minority of persons with type 2 diabetes. Analysis of US National Health and Nutrition Examination Survey (NHANES) datasets from 2007 through 2012 showed stage 3 or worse disease (estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2) in nearly one in five patients, with increasing age, blood pressure, obesity and levels of glycemia all associated with higher likelihood (1), comparable to findings from surveys from many other areas, which also show micro‐ or macroalbuminuria to be present in one sixth to one third of diabetic persons (2). Improvement in albuminuria has been shown in clinical trials of glycemic interventions, including the Action to Control Cardiovascular Disease in Diabetes (ACCORD) trial (3), the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial, in which the nephroprotective effect of blood pressure lowering was also demonstrated (4), and the United Kingdom Prospective Diabetes Study (UKPDS) (5).
Source: Journal of Diabetes - Category: Endocrinology Authors: Tags: Editorial Source Type: research