Clinical Hepatocyte Transplantation: What Is Next?

AbstractPurpose of ReviewSignificant recent scientific developments have occurred in the field of liver repopulation and regeneration. While techniques to facilitate liver repopulation with donor hepatocytes and different cell sources have been studied extensively in the laboratory, in recent years, clinical hepatocyte transplantation (HT) and liver repopulation trials have demonstrated new disease indications and also immunological challenges that will require the incorporation of a fresh look and new experimental approaches.Recent FindingsGrowth advantage and regenerative stimulus are necessary to allow donor hepatocytes to proliferate. Current research efforts focus on mechanisms of donor hepatocyte expansion in response to liver injury/preconditioning. Moreover, the latest clinical evidence shows that important obstacles to HT include optimizing engraftment and limited duration of effectiveness, with hepatocytes being lost to immunological rejection. We will discuss alternatives for cellular rejection monitoring, as well as new modalities to follow cellular graft function and near-to-clinical cell sources.SummaryHT partially corrects genetic disorders for a limited period of time and has been associated with reversal of acute liver failure. The main identified obstacles that remain to make HT a curative approach include improving engraftment rates, and methods for monitoring cellular graft function and rejection. This review aims to discuss current state of the art in cli...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

Related Links:

This article aims to describe the current seek medical status of chronic liver diseases and discuss a stage-based consulting medical model for chronic liver diseases in China mainland, which would contribute to make rational use of limited medical resources and help to address National Health China 2030 strategy initiated by the Chinese government. PMID: 31711913 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
This study aimed to determine the effects of back massage on postoperative vital signs, pain, and comfort levels in liver transplant patients.MethodsA quasi-experimental model with a pretest, a posttest, and a control group was used. The population of the study comprised adult patients who had liver transplantation for the first time. The study sample comprised 84 adult patients who had liver transplantation: 42 experimental (study group) and 42 control group, selected by power analysis and the random sampling method from the population. The data were collected between May and September 2016 using the short-form McGill Pai...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
Conditions:   Colorectal Cancer;   Liver Metastases;   Colorectal Liver Metastases Interventions:   Procedure: Liver transplantation Ltx;   Other: Best alternative care Sponsor:   Vastra Gotaland Region Not yet recruiting
Source: - Category: Research Source Type: clinical trials
(University of Colorado Anschutz Medical Campus) University of Colorado researchers have found lower vaccination rates among children who receive liver transplants, increasing the risk of sickness for those children, who already face significant health issues. The findings are discussed in a 'Research Letter' included in the November 12, 2019 issue of JAMA and also call attention to data that CU School of Medicine faculty members published earlier this year in JAMA Pediatrics.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
We read with great interest the article, ‘A multi-center study of entecavir vs. tenofovir on prognosis of treatment-naïve chronic hepatitis B in the Republic of Korea’ by Kim et al., published in the Journal of Hepatology.1 The authors concluded that the risk of hepatocellular carcinoma (HCC) and death or orthotopic liver transplant w as no different between entecavir (ETV) and tenofovir (TDF) groups. Their findings were not consistent with the results of a study by Choi et al.2
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
TUESDAY, Nov. 12, 2019 -- Many pediatric liver transplant recipients are undervaccinated, according to a research letter published in the Nov. 12 issue of the Journal of the American Medical Association. Amy G. Feldman, M.D., from the University of...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
No abstract available
Source: Annals of Surgery - Category: Surgery Tags: LETTERS AND REPLIES Source Type: research
No abstract available
Source: Annals of Surgery - Category: Surgery Tags: LETTERS AND REPLIES Source Type: research
This study characterizes the percentage of pediatric patients undergoing liver transplant who were up to date for their age on immunizations at the time of transplant and risk factors for underimmunization.
Source: JAMA - Category: General Medicine Source Type: research
More News: Allergy & Immunology | Genetics | Laboratory Medicine | Liver | Liver Transplant | Transplant Surgery | Transplants | Urology & Nephrology