Reactive oxygen species enhance mitochondrial function, insulin sensitivity and glucose uptake in skeletal muscle of senescence accelerated prone mice SAMP8.

In conclusion in muscle of SAMP8 compared to SAMR1, high ROS production is associated to higher insulin sensitivity and glucose uptake but to lower mitochondrial complex I activity. These conflicting adaptations, with regards to the resulting imbalance between NADH production and use, were associated with intrinsic adjustments in the mitochondrial respiration chain (mitochondrial uncoupling, enhanced complexes II and IV activity). We propose that these bioenergetics adaptations may help at preserving muscle metabolic flexibility of SAMP8.
PMID: 29024807 [PubMed - as supplied by publisher]

Source: Free Radical Biology and Medicine - October 9, 2017 Category: Biology Authors: Barquissau V, Capel F, Dardevet D, Feillet-Coudray C, Gallinier A, Chauvin MA, Rieusset J, Morio B Tags: Free Radic Biol Med Source Type: research