Serous carcinoma arising from adenomyosis
Adenomyosis (variant diseases of the endometriosis) is still a biggest challenge for both physicians and patients [1 –3]. Common symptoms and signs include an elevated of serum level of CA 125, dysmenorrhea, menorrhagia, and infertility [4,5]. Because of poor understanding of pathophysiology of adenomyosis , the current treatment strategy might be only limited to symptom treatment, including hormone thera py to induce menopause status, waiting for spontaneous menopause, and the destructive surgery, such as total hysterectomy and/or adenomyomectomy, cytoreduction of adenomyosis.
I have had insomnia for years, which I put down to the menopause. Now I ’ve come across research that suggests interrupted sleep in middle-age increases the risk of Alzheimer’s. What should I do? I am 62.
Conditions: Stomach Neoplasm; Peritoneal Carcinomatosis Interventions: Procedure: Cytoreductive surgery + Gastrecomy; Drug: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Sponsors: The Netherlands Cancer Institute; Erasmus Medical Center; St. Antonius Hospital; University Medical Center Groningen; Catharina Ziekenhuis Eindhoven Recruiting
Conditions: Surgery; Hysterectomy; Gynecologic Disease; Gynecologic Cancer; Anesthesia Interventions: Other: Changes in preoperative care; Other: Changes in intraoperative care; Other: Changes in postoperative care Sponsor: Azienda Ospedaliera Spedali Civili di Brescia Recruiting
Condition: Carcinoma, Hepatocellular Interventions: Drug: Regorafenib(Stivarga, BAY73-4506); Drug: Pembrolizumab Sponsors: Bayer; Merck Sharp & Dohme Corp. Not yet recruiting
UVR in sunlight causes mutations that drive basal cell carcinomas. However, the incidence of these tumors plateaus with prolonged exposure, but the incidence of other skin cancers increases. Makarova et al. now show that vitamin D3 produced in the skin by UVR protects against its oncogenic effects by inhibiting Hedgehog signaling, whereas dietary vitamin D3 does not.
CONCLUSION: Combined chemoradiation in treatment of anal cancer is effective in terms of local control and sphincter preservation. Five-year estimates of PFS, OS, as well as CFS, in patients treated with a MTB were surprisingly comparable to those determined in most non-MTB series. However, we reported a higher local failure rate, for which we are reevaluating our treatment protocol. Ann Saudi Med 2011; 31(2): 158-162PMID: 21403412 DOI: 10.4103/0256-4947.77488
Abstract Sensitivity enhancement and proteins adsorption are the common challenges faced in protein immunoassays. In this work, an ultrasensitive and protein-resistant label-free amperometric immunosening platform for carcinoma antigen-125 (CA125) based on redox polyaniline-polythionine hydrogel (PANI-PThi gel) was developed. The as-prepared hydrogel, which was facilely synthesized by electropolymerization, exhibited good conductivity and strong hydrophilicity while the sensitivity and specificity of the immunosensor can be enhanced. Furthermore, the as-prepared AuNPs functionalized PANI-PThi gel exhibited strong ...
We report a case of colorectal carcinoma with metastasis to the floor of the mouth. This is probably the first reported case of metastasis to the floor of the mouth in a patient with colorectal cancer. Ann Saudi Med 2011; 31(1): 87-89PMID: 20864784 DOI: 10.4103/0256-4947.70583
The steep decline in sperm counts is an opportunity to finally dispel the idea that fertility is primarily a women ’s issue
[Guardian] Lagos State University Teaching Hospital (LASUTH) has solicited for partnership to achieve affordable Assisted Reproductive Technology, ART, popularly known as In Vitro Fertilization (IVF) for indigent infertile couples.