Serous carcinoma arising from adenomyosis

Adenomyosis (variant diseases of the endometriosis) is still a biggest challenge for both physicians and patients [1 –3]. Common symptoms and signs include an elevated of serum level of CA 125, dysmenorrhea, menorrhagia, and infertility [4,5]. Because of poor understanding of pathophysiology of adenomyosis [6], the current treatment strategy might be only limited to symptom treatment, including hormone thera py to induce menopause status, waiting for spontaneous menopause, and the destructive surgery, such as total hysterectomy and/or adenomyomectomy, cytoreduction of adenomyosis.
Source: Taiwanese Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Correspondence Source Type: research

Related Links:

Menopause Package Intro ... TBD
Source: AARP.org News - Category: American Health Source Type: news
Authors: Altinoz MA, Ozpinar A, Alturfan EE, Elmaci I Abstract Vinorelbine is a very potent chemotherapeutic agent which is used to treat a number of cancers including breast and non-small cell lung tumors. Vinorelbine mainly acts via blocking microtubules and induces a specific type of cell death called 'mitotic catastrophe/apoptosis' subsequent to mitotic slippage, which is the failure of cells to stay in a mitotic arrested state and replicating their DNA without cytokinesis. Glial tumor cells are especially sensitive to mitotic slippage. In recent years, vinorelbine demonstrated potency in pediatric optic and po...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
AbstractThe incidence of esophageal adenocarcinoma (EAC) has increased significantly in Western countries. The rising prevalence of gastroesophageal reflux disease (GERD) and obesity has played a major role in the increasing numbers of EAC. Approximately 10 –15% of patients with GERD will develop Barrett’s esophagus (BE). This metaplastic transformation is due to the chronic injury produced by repeated reflux episodes and involves genetic mutations that can lead to a malignant transformation. Ultimately, the development of EAC is characterized by t he sequence BE metaplasia–dysplasia–invasive carcinoma.
Source: Updates in Surgery - Category: Surgery Source Type: research
Lauren C. J. Baker, Arti Sikka, Jonathan M. Price, Jessica K. R. Boult, Elise Y. Lepicard, Gary Box, Yann Jamin, Terry J. Spinks, Gabriela Kramer-Marek, Martin O. Leach, Suzanne A. Eccles, Carol Box, Simon P. Robinson
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractWe compared the characteristics, clinical behavior, and biomarker profile between HER2 positive (HER2+) and triple-negative (TN) ductal carcinoma in situ (DCIS) which are considered more aggressive than other DCIS subtypes. In addition, we explored the impact of these features on its potential of progression to invasive breast carcinomas. Cases of DCIS diagnosed at the Department of Pathology, Singapore General Hospital from 1994 to 2010 were identified. TN and HER2+ DCIS cases formed the study cohort. Immunohistochemistry (IHC) was performed for ER, PR, HER2, CK14, EGFR, and p53. Comparisons of clinicopathological...
Source: Virchows Archiv - Category: Pathology Source Type: research
ana Berindan-Neagoe Smoking is a well-known behavior that has an important negative impact on human health, and is considered to be a significant factor related to the development and progression of head and neck squamous cell carcinomas (HNSCCs). Use of high-dimensional datasets to discern novel HNSCC driver genes related to smoking represents an important challenge. The Cancer Genome Atlas (TCGA) analysis was performed in three co-existing groups of HNSCC in order to assess whether gene expression landscape is affected by tobacco smoking, having quit, or non-smoking status. We identified a set of differentially expre...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Inamoto T, Uehara H, Akao Y, Ibuki N, Komura K, Takahara K, Takai T, Uchimoto T, Saito K, Tanda N, Yoshikawa Y, Minami K, Hirano H, Nomi H, Kato R, Hayashi T, Azuma H Abstract Introduction and Objectives: MicroRNA (miRNA) expression is altered in urologic malignancies, including urothelial carcinoma of the bladder (UCB). Individual miRNAs have been shown to modulate multiple signaling pathways that contribute to BC. To identify a panel of miRNA signature that can predict aggressive phenotype from normal nonaggressive counterpart using miRNA expression levels and to assess the prognostic value of this speci...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Conclusions: Only early menopause was associated with an increased risk of OAG in our study, in contrast to previous Western studies reporting both early menopause and late menarche as associated factors. PMID: 30026984 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
This study investigated the prognostic value of the fibrinogen/albumin ratio in HCC patients who underwent curative resection. Methods: HCC patients (n = 151) who underwent curative resection were evaluated retrospectively. The optimal cutoff value for the fibrinogen/albumin ratio was selected by receiver operating characteristic (ROC) curve analysis. Correlations between preoperative fibrinogen/albumin ratios and clinicopathologic characteristics were analyzed by χ2 test. The area under the receiver operating characteristic curve (AUC) was calculated to compare the prognostic value of the fibrinogen/albumin ratio ...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
The aim of this study is to investigate the antitumor activity and possible molecular mechanism of Phenethyl isothiocyanate (PEITC) against Ehrlich ascites carcinoma in-vivo and in-vitro.In-vivo, ascetic fluid volume, body weight, serum malondialdehyde (MDA) level and total antioxidant capacity (TAC) were determined using Ehrlich ascites carcinoma (EAC) bearing mice. In-vitro, MTT assay was used. RT-PCR was used to investigate role of PEITC in apoptosis by analyzing the expression of Bax, caspase-9, and Bcl-2 genes. The effect of PEITC on caspase-9 enzyme activity was also tested.PEITC and/or Doxorubicin (Dox) treatment si...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
More News: Cancer & Oncology | Carcinoma | Chia | Endometriosis | Hormones | Hysterectomy | Infertility | Men | Menopause | OBGYN | Reproduction Medicine | Serous Carcinoma | Taiwan Health