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Serous carcinoma arising from adenomyosis

Adenomyosis (variant diseases of the endometriosis) is still a biggest challenge for both physicians and patients [1 –3]. Common symptoms and signs include an elevated of serum level of CA 125, dysmenorrhea, menorrhagia, and infertility [4,5]. Because of poor understanding of pathophysiology of adenomyosis [6], the current treatment strategy might be only limited to symptom treatment, including hormone thera py to induce menopause status, waiting for spontaneous menopause, and the destructive surgery, such as total hysterectomy and/or adenomyomectomy, cytoreduction of adenomyosis.
Source: Taiwanese Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Correspondence Source Type: research

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ABSTRACT Deciphering the complex milieu that makes up the tumor microenvironment (TME) and the signaling engaged by TME cytokines continues to provide novel targets for therapeutic intervention. The IL‐6 family member Oncostatin M (OSM) has recently emerged as a potent driver of tumorigenesis, metastasis and therapy failure, molecular programs most frequently attributed to IL‐6 itself. In a recent issue of The Journal of Pathology, Kucia‐Tran et al. describe how elevated Oncostatin M receptor (OSMR) expression results in a feed‐forward loop involving the de novo production of both OSM and OSMR to facilitate aggress...
Source: The Journal of Pathology - Category: Pathology Authors: Tags: Invited Commentary Source Type: research
Abstract Background and aimMac‐2‐binding protein glycosylation isomer (M2BPGi) was recently identified as a serum glycobiomarker for liver fibrosis. However, the relationship between M2BPGi and malnutrition in patients with chronic liver disease (CLD) is unknown. We aimed to evaluate whether M2BPGi could be a surrogate marker for malnutrition in patients with CLD. MethodsIn total, 338 outpatients with CLD were enrolled (median age: 67 years). We evaluated the associations among liver fibrosis markers (M2BPGi, FIB‐4 index, and aspartate aminotransferase to platelet count ratio index), Child‐Pugh stages, and nutritio...
Source: Journal of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Hepatology Source Type: research
ConclusionIt is feasible and safe to use this novel, flexible, single‐arm robot in performing a transoral robotic radical tonsillectomy and retropharyngeal lymph node dissection.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: OPERATIVE TECHNIQUES Source Type: research
Authors: Frey J, Dorofte L, Sundqvist P PMID: 29463171 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
A Queensland mother-of-two went through menopause at just 32 after she had both of her ovaries removed due to a high-risk of cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusions: Decisions regarding the use of HT in women who undergo BSO after detection of a BRCA mutation must be individualized based on careful consideration of the risks and benefits. However, the risks of a subsequent cancer diagnosis appear small, particularly in regards to the benefits of treatment afforded by HT.
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research
Authors: Li F, Qiao CY, Gao S, Fan YC, Chen LY, Wang K Abstract BACKGROUND AND AIM: The initiation and progression of hepatocellular carcinoma (HCC) is a multistage process involving a variety of changes at the gene level. Insulin-like growth factor binding protein 7 (IGFBP7) methylation plays a crucial role in HCC development. The main purpose of this study was to investigate the relationship between oxidative stress, DNA methyltransferases (DNMTs) expression and IGFBP7 methylation, and to evaluate the prognostic value of serum IGFBP7 methylation status in patients with HCC after hepatectomy. METHODS: We enrol...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
This study investigated the relationship between obesity and sleep architecture in postmenopausal women.Menopause
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news
Authors: Sangro P, Bilbao I, Fernández-Ros N, Iñarrairaegui M, Zulueta J, Bilbao JI, Sangro B Abstract Sorafenib is a multi-kinase inhibitor and a vascular endothelial growth factor (VEGF) inhibitor approved to treat patients with advanced hepatocellular carcinoma, renal cell carcinoma and differentiated thyroid carcinoma. Its most common side effects are asthenia/fatigue, skin toxicity, diarrhea and arterial hypertension. Reported respiratory adverse reactions include dyspnea, cough, pleural effusion and hoarseness. The aim of this report is to describe for the first time the occurrence of pneumatoce...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In this study, we exposed HCC cells to TGF-β2 (Transforming Growth Factor-β2), which resulted in a significant elevation of EMT (Epithelial to Mesenchymal Transition) like features. Molecular analysis of EMT markers showed an increase at both RNA and protein levels upon TGF-β2 administration along with up-regulation of TGF-β-induced Smad signaling. Induction of EMT was associated with a simultaneous increase in reactive oxygen species (ROS) and cytostasis of TGF-β2-treated cells. Importantly, quenching of ROS resulted in a significant promotion of TGF-β2-induced EMT. Furthermore, cells treated...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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