Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response

The incretin effect is impaired in type 2 diabetes (T2D), but the underlying mechanisms are only partially understood. We investigated the relationships between the time course of the incretin effect and that of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) during oral glucose tolerance tests (OGTTs), thereby estimating incretin sensitivity of the beta cell, and its associated factors.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2017 Category: Nutrition Authors: A. Tura, J.I. Bagger, E. Ferrannini, J.J. Holst, F.K. Knop, T. Vilsb øll, A. Mari Source Type: research